Valeriote F, Vietti T
Cancer Drug Deliv. 1985 Winter;2(1):11-8. doi: 10.1089/cdd.1985.2.11.
Both cytotoxicity and host toxicity were examined for the alkylating agents HN2, BCNU and L-PAM administered intravenously (IV) either as a single bolus injection or a 24-hour infusion. The bolus injection was more effective than the infusion schedule at a given dose for BCNU and L-PAM. Unexpectedly, the HN2 infusion schedule was more effective than bolus injection at a given dose. When host survival was the endpoint, both HN2 and L-PAM were shown to be more effective by the infusion schedule.
对静脉注射（IV）的烷化剂氮芥（HN2）、卡莫司汀（BCNU）和左旋苯丙氨酸氮芥（L-PAM）进行了细胞毒性和宿主毒性检测，给药方式为单次大剂量注射或24小时输注。对于BCNU和L-PAM，在给定剂量下，大剂量注射比输注方案更有效。出乎意料的是，在给定剂量下，HN2的输注方案比大剂量注射更有效。当以宿主存活作为终点指标时，HN2和L-PAM的输注方案均显示出更有效。
