Weng Bob, Morrissey Reid, Lehn Jenna, Beidas Mustafa, Abubakar Tauseef, Mirza Mohsin
Creighton University School of Medicine, Omaha, NE, United States of America.
Creighton University Department of Internal Medicine, CHI Health Bergan Mercy Hospital, Omaha, NE, United States of America.
Compr Psychoneuroendocrinol. 2025 Jun 4;23:100305. doi: 10.1016/j.cpnec.2025.100305. eCollection 2025 Aug.
Polycystic ovarian syndrome (PCOS) is a dysregulated metabolic disorder causing hyperandrogenism, oligomenorrhea/anovulation, and ovarian cysts. The effects of PCOS extend beyond the reproductive detriments, notably an association with mood disorders. Existing literature is limited but suggests comorbid mood derangements increase the severity of PCOS symptoms and comprise a significant portion of healthcare costs in the U.S. Our study aims to further examine the impact of PCOS on the hospitalization course and costs.
Using data for females ages 18-50 from the National Inpatient Sample (NIS) between 2016 and 2020, a PCOS group was compared to a non-PCOS group for women hospitalized with mood disorders. Length of stay (LOS), hospital costs, and demographic characteristics were analyzed.
PCOS patients accumulated significantly higher LOS and hospital cost. They also were significantly younger, predominantly Caucasian, covered by private insurance, and earned more income. There was a disproportionate use of Medicare for both groups given the younger sample.
Further investigation of demographic nuances and a multidisciplinary approach to PCOS, including policy changes and patient education starting at a young age, should be taken to better understand disease impact on different communities and address the broad scope of the disease (i.e. psychosocial) to reduce its healthcare burden.
多囊卵巢综合征（PCOS）是一种代谢失调的疾病，会导致高雄激素血症、月经过少/无排卵以及卵巢囊肿。PCOS的影响不仅限于生殖方面的损害，尤其与情绪障碍有关。现有文献有限，但表明合并情绪紊乱会增加PCOS症状的严重程度，且在美国医疗费用中占很大一部分。我们的研究旨在进一步探讨PCOS对住院病程和费用的影响。
利用2016年至2020年全国住院患者样本（NIS）中18至50岁女性的数据，将因情绪障碍住院的女性的PCOS组与非PCOS组进行比较。分析住院时间（LOS）、住院费用和人口统计学特征。
PCOS患者的住院时间和住院费用显著更高。他们也明显更年轻，主要是白种人，有私人保险，收入更高。鉴于样本较年轻，两组对医疗保险的使用都不成比例。
应进一步调查人口统计学细微差别，并采用多学科方法治疗PCOS，包括政策改变和从年轻时就开始的患者教育，以更好地了解该疾病对不同群体的影响，并应对该疾病广泛的（即心理社会方面的）问题，以减轻其医疗负担。
