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本文引用的文献

1
Preliminary outcomes of the Cervical Cancer Screening Program of Northern Portugal: A snapshot.葡萄牙北部宫颈癌筛查计划的初步结果：一个快照。
J Infect Public Health. 2024 Jun;17(6):1057-1064. doi: 10.1016/j.jiph.2024.04.020. Epub 2024 Apr 28.
2
DNA methylation as a triage marker for colposcopy referral in HPV-based cervical cancer screening: a systematic review and meta-analysis.基于 HPV 的宫颈癌筛查中 DNA 甲基化作为阴道镜转诊的分流标志物：系统评价和荟萃分析。
Clin Epigenetics. 2023 Aug 2;15(1):125. doi: 10.1186/s13148-023-01537-2.
3
Impact of high-risk Human Papillomavirus genotyping in cervical disease in the Northern region of Portugal: Real-world data from regional cervical cancer screening program.高危型人乳头瘤病毒基因分型对葡萄牙北部地区宫颈疾病的影响：来自地区宫颈癌筛查项目的真实世界数据
J Med Virol. 2023 Jan;95(1):e28414. doi: 10.1002/jmv.28414.
4
DigiMir Test: Establishing a Novel Pipeline for MiR-371a Quantification Using Droplet Digital PCR in Liquid Biopsies From Testicular Germ Cell Tumor Patients.数字微滴式逆转录聚合酶链反应检测：利用液滴数字PCR在睾丸生殖细胞肿瘤患者的液体活检中建立一种用于定量检测miR-371a的新型流程。
Front Oncol. 2022 Jun 10;12:876732. doi: 10.3389/fonc.2022.876732. eCollection 2022.
5
Performance of DNA methylation-based biomarkers in the cervical cancer screening program of northern Portugal: A feasibility study.基于 DNA 甲基化的生物标志物在葡萄牙北部宫颈癌筛查计划中的表现：一项可行性研究。
Int J Cancer. 2021 Dec 1;149(11):1916-1925. doi: 10.1002/ijc.33778. Epub 2021 Sep 12.
6
A study of type-specific HPV natural history and implications for contemporary cervical cancer screening programs.一项关于特定类型人乳头瘤病毒自然史及其对当代宫颈癌筛查项目影响的研究。
EClinicalMedicine. 2020 Apr 25;22:100293. doi: 10.1016/j.eclinm.2020.100293. eCollection 2020 May.
7
Performance of DNA methylation assays for detection of high-grade cervical intraepithelial neoplasia (CIN2+): a systematic review and meta-analysis.用于检测高级别宫颈上皮内瘤变（CIN2+）的 DNA 甲基化检测方法的性能：系统评价和荟萃分析。
Br J Cancer. 2019 Nov;121(11):954-965. doi: 10.1038/s41416-019-0593-4. Epub 2019 Oct 16.
8
Primary HPV-based cervical cancer screening in Europe: implementation status, challenges, and future plans.欧洲基于 HPV 的宫颈癌初筛：实施现状、挑战与未来计划。
Clin Microbiol Infect. 2020 May;26(5):579-583. doi: 10.1016/j.cmi.2019.09.006. Epub 2019 Sep 17.
9
Long-term CIN3+ risk of HPV positive women after triage with FAM19A4/miR124-2 methylation analysis.HPV 阳性女性经 FAM19A4/miR124-2 甲基化分析进行分流后的长期 CIN3+风险。
Gynecol Oncol. 2019 Aug;154(2):368-373. doi: 10.1016/j.ygyno.2019.06.002. Epub 2019 Jun 8.
10
Methylation marker analysis and HPV16/18 genotyping in high-risk HPV positive self-sampled specimens to identify women with high grade CIN or cervical cancer.高危型 HPV 阳性自我采样标本中甲基化标志物分析和 HPV16/18 基因分型，以识别患有高级别 CIN 或宫颈癌的女性。
Gynecol Oncol. 2014 Oct;135(1):58-63. doi: 10.1016/j.ygyno.2014.08.003. Epub 2014 Aug 8.

Methylation-Specific Droplet Digital PCR: Testing a Novel Triage Tool for HrHPV-Positive Women in the Cervical Cancer Screening Program of Northern Portugal.

作者信息

Salta Sofia, Sequeira José Pedro, Amorim-Fernandes Bárbara, Lobo João, Baldaque Inês, Monteiro Paula, Tavares Fernando, Taly Valérie, Henrique Rui, Jerónimo Carmen

机构信息

Cancer Biology & Epigenetics Group Research Center of IPO Porto (CI-IPOP) Portuguese Oncology Institute of Porto (IPO Porto) Porto Comprehensive Cancer Center Raquel Seruca (Porto.CCC) R. Dr. António Bernardino de Almeida Porto Portugal.

Doctoral Program in Molecular Pathology and Genetics ICBAS-School of Medicine and Biomedical Sciences-University of Porto Rua Jorge Viterbo Ferreira Porto Portugal.

出版信息

MedComm (2020). 2025 Jun 15;6(7):e70203. doi: 10.1002/mco2.70203. eCollection 2025 Jul.

DOI:10.1002/mco2.70203
PMID:40529612
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12167703/
Abstract
摘要