老年人髋部骨折的新型蛋白质组学见解：揭示免疫生物标志物、时间表达模式及临床相关性
Novel Proteomic Insights into Hip Fractures in the Elderly: Unraveling Immunologic Biomarkers, Temporal Expression Patterns, and Clinical Correlations.
作者信息
Lu Yining, Liu Jiaoran, Chen Wei, Hu Pan, Pei Yan, Gao Yiming, Lu Hairong, Wang Ling, Zhang Yingze
机构信息
Department of Orthopedic Research Center, The Third Hospital of Hebei Medical University, Shijiazhuang, Hebei, People's Republic of China.
Department of Orthopedic Oncology, The Third Hospital of Hebei Medical University, Shijiazhuang, Hebei, People's Republic of China.
出版信息
J Inflamm Res. 2025 Jun 12;18:7703-7716. doi: 10.2147/JIR.S513035. eCollection 2025.
BACKGROUND
Hip fractures in the elderly triggers a severe inflammatory immune response.
METHODS
Peripheral blood samples from 16 elderly hip fracture patients and 16 healthy controls were analysed for 92 inflammatory biomarkers using proximity extension assay (PEA) at different stages after trauma.
RESULTS
Dynamic trends in inflammatory proteins after surgery were assessed. Correlation analyses showed significant associations between inflammation-related proteins and clinical parameters. A prognostic risk score model was developed: on day 1, CCL19, FGF-19 and MCP-2 were significant; on day 3, TGF-α, FGF-5, CCL19, IL-22RA1 and IL-12B were included; and on day 7, IL-2RB, CCL19 and 4E-BP1 were significant. High-risk patients had a significantly lower rate of recovery compared with low-risk patients.
CONCLUSION
In this study, we have highlighted the complex inflammatory response during fracture healing and emphasised the importance of long-term monitoring of protein dynamics.
背景
老年髋部骨折会引发严重的炎症免疫反应。
方法
采用邻近延伸分析（PEA），在创伤后的不同阶段，对16例老年髋部骨折患者和16例健康对照者的外周血样本进行92种炎症生物标志物分析。
结果
评估了术后炎症蛋白的动态变化趋势。相关性分析显示炎症相关蛋白与临床参数之间存在显著关联。建立了一个预后风险评分模型：术后第1天，CCL19、FGF-19和MCP-2具有显著意义；术后第3天，纳入TGF-α、FGF-5、CCL19、IL-22RA1和IL-12B；术后第7天，IL-2RB、CCL19和4E-BP1具有显著意义。与低风险患者相比，高风险患者的恢复率显著更低。
结论
在本研究中，我们突出了骨折愈合过程中复杂的炎症反应，并强调了长期监测蛋白动态变化的重要性。
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