Evaluating liver resection outcomes post Y90 TARE with personalized dosimetry in intermediate or advanced hepatocellular carcinoma: a focus on surgical and biliary complications.

BACKGROUND

While preliminary reports on resection following downstaging using transarterial radioembolization (TARE) for intermediate or advanced hepatocellular carcinomas (HCCs) reported promising oncological outcomes, there's a notable gap in the literature concerning post operative morbidity. Contrary to post hepatectomy liver failure (PHLF), damages to the bile ducts and their potential consequences have been poorly evaluated. Thus, our aim was to explore postoperative complications in HCC patients undergoing liver resection after Y90 TARE, focusing particularly on biliary complications.

METHODS

Conducted from June 2015 to December 2022, this retrospective study involved 30 HCC patients undergoing liver resection post-TARE. Comprehensive data on surgical procedures, complications, and follow-up were collected. Logistic regression analyses were conducted, starting with univariate analysis followed by multivariate analysis, focusing on variables with a significance level below P<0.2.

RESULTS

The objective response rate (ORR) in the TARE-treated area was 97% at 3 months. Survival outcomes showed a median overall survival (OS) of 5.1 years and progression-free survival (PFS) of 3.5 years post-liver resection. The study found a 40% (12 out of 30 patients) rate of severe postoperative complications and a 7% (2 out of 30 patients) 90-day mortality rate. After liver resection, grade B bile leaks occurred in 20% (6 out of 30) of patients, with a third experiencing recurrence. Biliary-specific mortality was 9%. After multivariate analysis, only the interval between TARE and surgery emerged a significant risk factor for biliary complications, showing increased odds of bile leaks if surgery occurred 3-6 months post-TARE compared to after 6 months.

CONCLUSIONS

This study highlights the importance of timing between TARE and surgery, suggesting a waiting period of at least 6 months. Such timing not only enhances the radiation effects of TARE but also optimizes both future liver remnant growth and patient selection.