Zhang L, Chen Y, Ao Y, Qi Y
Affiliated Hospital of Chengde Medical University, Chengde, China.
Acta Endocrinol (Buchar). 2024 Jul-Sep;20(3):304-310. doi: 10.4183/aeb.2024.304. Epub 2025 May 23.
To analyze the clinical value of dissection parathyroidectomy (DP) in patients with chronic kidney disease (CKD) complicated by refractory secondary hyperparathyroidism (HPT).
Patients with CKD complicated by refractory secondary HPT were included as the research subjects. Among them, 42 patients who received DP were assigned as the study group, while another 42 patients who underwent conventional total parathyroidectomy were assigned as the control group.
The average operative time and postoperative average length of hospital stay of the study group were lower than those of the control group (P<0.05). The study group showed lower levels of parathyroid hormone (PTH) compared to the control group 1 day postoperatively, 7 days postoperatively, 6 months postoperatively, and 12 months postoperatively (P<0.05). The study group exhibited lower serum calcium levels than the control group 1 day postoperatively, 7 days postoperatively, 1 month postoperatively, and 6 months postoperatively (P<0.05). Additionally, the study group demonstrated lower serum phosphorus levels compared to the control group 1 day postoperatively, 7 days postoperatively, and 6 months postoperatively (P<0.05).
The application of DP in patients with CKD complicated by refractory secondary HPT holds definite clinical value.
分析甲状旁腺次全切除术（DP）在慢性肾脏病（CKD）合并难治性继发性甲状旁腺功能亢进（HPT）患者中的临床价值。
将CKD合并难治性继发性HPT患者纳入研究对象。其中，42例行DP的患者作为研究组，另外42例行传统甲状旁腺全切术的患者作为对照组。
研究组的平均手术时间和术后平均住院时间均低于对照组（P<0.05）。术后1天、术后7天、术后6个月和术后12个月，研究组的甲状旁腺激素（PTH）水平均低于对照组（P<0.05）。术后1天、术后7天、术后1个月和术后6个月，研究组的血清钙水平低于对照组（P<0.05）。此外，术后1天、术后7天和术后6个月，研究组的血清磷水平低于对照组（P<0.05）。
DP应用于CKD合并难治性继发性HPT患者具有一定的临床价值。
