用于不可治愈的复发性/转移性头颈部鳞状细胞癌（RM HNSCC）的程序性细胞死亡1抑制剂的新型联合用药：卡博替尼是领跑者吗？ - Suppr

Suppr

超能文献

Novel combinations with programmed cell death 1 inhibitor for incurable recurrent/metastatic head and neck squamous cell carcinoma (RM HNSCC): is cabozantinib a front runner?

作者信息

Bhateja Priyanka, Bonomi Marcelo, Verschraegen Claire

机构信息

Department of Medical Oncology, Ohio State University, James Cancer Center, Columbus, OH, USA.

出版信息

Transl Cancer Res. 2025 May 30;14(5):2548-2552. doi: 10.21037/tcr-2024-2569. Epub 2025 May 13.

DOI:10.21037/tcr-2024-2569

PMID:40530149

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12170040/

Abstract

摘要

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Novel combinations with programmed cell death 1 inhibitor for incurable recurrent/metastatic head and neck squamous cell carcinoma (RM HNSCC): is cabozantinib a front runner?用于不可治愈的复发性/转移性头颈部鳞状细胞癌（RM HNSCC）的程序性细胞死亡1抑制剂的新型联合用药：卡博替尼是领跑者吗？

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本文引用的文献

A phase II study of monalizumab and durvalumab in patients with recurrent/metastatic squamous cell carcinoma of the head and neck: results of the I2 cohort of the EORTC-HNCG-1559 trial (UPSTREAM).莫纳利珠单抗与度伐利尤单抗治疗复发/转移性头颈部鳞状细胞癌的II期研究：EORTC-HNCG-1559试验（UPSTREAM）I2队列的结果

ESMO Open. 2025 Apr 30;10(5):104554. doi: 10.1016/j.esmoop.2025.104554.

Pembrolizumab and Cabozantinib in Recurrent and/or Metastatic Head and Neck Squamous Cell Carcinoma: Long-term Survival Update with a Biomarker Analysis.帕博利珠单抗联合卡博替尼治疗复发性和/或转移性头颈部鳞状细胞癌：基于生物标志物分析的长期生存更新。

Clin Cancer Res. 2024 Oct 15;30(20):4601-4608. doi: 10.1158/1078-0432.CCR-24-1202.

Pembrolizumab and cabozantinib in recurrent metastatic head and neck squamous cell carcinoma: a phase 2 trial.派姆单抗联合卡博替尼治疗复发性转移性头颈部鳞状细胞癌：一项 2 期临床试验。

Nat Med. 2023 Apr;29(4):880-887. doi: 10.1038/s41591-023-02275-x. Epub 2023 Apr 3.

Durvalumab with or without tremelimumab versus the EXTREME regimen as first-line treatment for recurrent or metastatic squamous cell carcinoma of the head and neck: KESTREL, a randomized, open-label, phase III study.度伐利尤单抗联合或不联合曲美木单抗对比EXTREME方案作为复发性或转移性头颈部鳞状细胞癌一线治疗的疗效：KESTREL，一项随机、开放标签的III期研究。

Ann Oncol. 2023 Mar;34(3):262-274. doi: 10.1016/j.annonc.2022.12.008. Epub 2022 Dec 16.

Nivolumab Plus Ipilimumab Versus EXTREME Regimen as First-Line Treatment for Recurrent/Metastatic Squamous Cell Carcinoma of the Head and Neck: The Final Results of CheckMate 651.纳武利尤单抗联合伊匹木单抗对比 EXTREME 方案作为复发/转移性头颈部鳞癌一线治疗：CheckMate 651 的最终结果。

J Clin Oncol. 2023 Apr 20;41(12):2166-2180. doi: 10.1200/JCO.22.00332. Epub 2022 Dec 6.

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