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Novel combinations with programmed cell death 1 inhibitor for incurable recurrent/metastatic head and neck squamous cell carcinoma (RM HNSCC): is cabozantinib a front runner?

作者信息

Bhateja Priyanka, Bonomi Marcelo, Verschraegen Claire

机构信息

Department of Medical Oncology, Ohio State University, James Cancer Center, Columbus, OH, USA.

出版信息

Transl Cancer Res. 2025 May 30;14(5):2548-2552. doi: 10.21037/tcr-2024-2569. Epub 2025 May 13.

DOI:10.21037/tcr-2024-2569
PMID:40530149
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12170040/
Abstract
摘要

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Novel combinations with programmed cell death 1 inhibitor for incurable recurrent/metastatic head and neck squamous cell carcinoma (RM HNSCC): is cabozantinib a front runner?用于不可治愈的复发性/转移性头颈部鳞状细胞癌（RM HNSCC）的程序性细胞死亡1抑制剂的新型联合用药：卡博替尼是领跑者吗？
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2
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World J Clin Oncol. 2022 May 24;13(5):388-411. doi: 10.5306/wjco.v13.i5.388.
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本文引用的文献

1
A phase II study of monalizumab and durvalumab in patients with recurrent/metastatic squamous cell carcinoma of the head and neck: results of the I2 cohort of the EORTC-HNCG-1559 trial (UPSTREAM).莫纳利珠单抗与度伐利尤单抗治疗复发/转移性头颈部鳞状细胞癌的II期研究：EORTC-HNCG-1559试验（UPSTREAM）I2队列的结果
ESMO Open. 2025 Apr 30;10(5):104554. doi: 10.1016/j.esmoop.2025.104554.
2
Pembrolizumab and Cabozantinib in Recurrent and/or Metastatic Head and Neck Squamous Cell Carcinoma: Long-term Survival Update with a Biomarker Analysis.帕博利珠单抗联合卡博替尼治疗复发性和/或转移性头颈部鳞状细胞癌：基于生物标志物分析的长期生存更新。
Clin Cancer Res. 2024 Oct 15;30(20):4601-4608. doi: 10.1158/1078-0432.CCR-24-1202.
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Pembrolizumab and cabozantinib in recurrent metastatic head and neck squamous cell carcinoma: a phase 2 trial.
派姆单抗联合卡博替尼治疗复发性转移性头颈部鳞状细胞癌：一项 2 期临床试验。
Nat Med. 2023 Apr;29(4):880-887. doi: 10.1038/s41591-023-02275-x. Epub 2023 Apr 3.
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Durvalumab with or without tremelimumab versus the EXTREME regimen as first-line treatment for recurrent or metastatic squamous cell carcinoma of the head and neck: KESTREL, a randomized, open-label, phase III study.度伐利尤单抗联合或不联合曲美木单抗对比EXTREME方案作为复发性或转移性头颈部鳞状细胞癌一线治疗的疗效：KESTREL，一项随机、开放标签的III期研究。
Ann Oncol. 2023 Mar;34(3):262-274. doi: 10.1016/j.annonc.2022.12.008. Epub 2022 Dec 16.
5
Nivolumab Plus Ipilimumab Versus EXTREME Regimen as First-Line Treatment for Recurrent/Metastatic Squamous Cell Carcinoma of the Head and Neck: The Final Results of CheckMate 651.纳武利尤单抗联合伊匹木单抗对比 EXTREME 方案作为复发/转移性头颈部鳞癌一线治疗：CheckMate 651 的最终结果。
J Clin Oncol. 2023 Apr 20;41(12):2166-2180. doi: 10.1200/JCO.22.00332. Epub 2022 Dec 6.
6
Immunotherapy for head and neck cancer: Present and future.头颈部癌症的免疫治疗：现状与未来。
Crit Rev Oncol Hematol. 2022 Jun;174:103679. doi: 10.1016/j.critrevonc.2022.103679. Epub 2022 Apr 6.
7
Phase II Multi-institutional Clinical Trial Result of Concurrent Cetuximab and Nivolumab in Recurrent and/or Metastatic Head and Neck Squamous Cell Carcinoma.复发和/或转移性头颈部鳞状细胞癌中同步西妥昔单抗和纳武利尤单抗的多机构 II 期临床试验结果。
Clin Cancer Res. 2022 Jun 1;28(11):2329-2338. doi: 10.1158/1078-0432.CCR-21-3849.
8
Immunogenic Cell Death and Immunomodulatory Effects of Cabozantinib.卡博替尼的免疫原性细胞死亡及免疫调节作用
Front Oncol. 2021 Oct 20;11:755433. doi: 10.3389/fonc.2021.755433. eCollection 2021.
9
Pembrolizumab plus cetuximab in patients with recurrent or metastatic head and neck squamous cell carcinoma: an open-label, multi-arm, non-randomised, multicentre, phase 2 trial.帕博利珠单抗联合西妥昔单抗治疗复发性或转移性头颈部鳞状细胞癌患者的开放标签、多臂、非随机、多中心、2 期临床试验。
Lancet Oncol. 2021 Jun;22(6):883-892. doi: 10.1016/S1470-2045(21)00136-4. Epub 2021 May 11.
10
Bintrafusp alfa, a bifunctional fusion protein targeting TGF-β and PD-L1, in advanced squamous cell carcinoma of the head and neck: results from a phase I cohort.双功能融合蛋白靶向 TGF-β和 PD-L1 的 Bintrafusp alfa 治疗头颈部鳞状细胞癌的 I 期队列研究结果。
J Immunother Cancer. 2020 Jul;8(2). doi: 10.1136/jitc-2020-000664.