Li Andy, Saxena Parima, Thida Aye M, Nnadi Ekenedilichukwu N, Brown Jordonna
Internal Medicine, State University of New York Downstate Medical Center, Brooklyn, USA.
Hematology and Medical Oncology, State University of New York Downstate Medical Center, Brooklyn, USA.
Cureus. 2025 May 18;17(5):e84350. doi: 10.7759/cureus.84350. eCollection 2025 May.
Purpura fulminans (PF) is a rapidly progressive, life-threatening condition marked by ecchymotic, tender, and symmetric skin lesions, often resulting from disseminated intravascular coagulation (DIC) secondary to infectious or non-infectious etiologies. PF usually occurs in immunocompromised hosts and is associated with a high mortality rate. Here, we highlight a case of an elderly immunocompetent woman with DIC and subsequent PF. Her case underscores the importance of early intervention in managing this rare but deadly condition in order to ensure optimal survival outcomes. Early intervention for PF with DIC includes the timely administration of antibiotics, steroids, and anticoagulants, along with addressing the underlying consumptive coagulopathy.
暴发性紫癜（PF）是一种迅速进展、危及生命的疾病，其特征为瘀斑、压痛且对称的皮肤损害，通常由感染性或非感染性病因继发的弥散性血管内凝血（DIC）引起。PF通常发生在免疫功能低下的宿主中，且死亡率很高。在此，我们重点介绍一例患有DIC并继发PF的免疫功能正常的老年女性病例。她的病例强调了早期干预对于管理这种罕见但致命疾病的重要性，以确保获得最佳生存结果。对伴有DIC的PF进行早期干预包括及时使用抗生素、类固醇和抗凝剂，同时处理潜在的消耗性凝血病。
