Cadena-Ullauri Santiago, Guevara-Ramírez Patricia, Paz-Cruz Elius, Ruiz-Pozo Viviana A, Tamayo-Trujillo Rafael, Zambrano Ana Karina
Universidad UTE, Facultad de Ciencias de la Salud Eugenio Espejo, Centro de Investigación Genética y Genómica, Quito, Ecuador.
Front Cell Dev Biol. 2025 Jun 2;13:1589726. doi: 10.3389/fcell.2025.1589726. eCollection 2025.
This review explores the impact of gut microbiota dysbiosis on thyroid hormone metabolism and its potential association with thyroid cancer. The analysis highlights specific bacterial genera linked to thyroid dysfunction, the role of gut microbiota in iodine absorption, and mechanisms connecting dysbiosis with thyroid disorders such as hypothyroidism, hyperthyroidism, Hashimoto's thyroiditis, and Graves' disease. Additionally, it examines the potential of gut microbiota as a biomarker for diagnosis and personalized treatment, as well as the prospect of probiotics and microbiota-targeted treatments. The review emphasizes the importance of conducting additional research to fully understand microbiota-thyroid interactions and develop appropriate therapies to improve clinical outcomes and patient quality of life.
本综述探讨了肠道微生物群失调对甲状腺激素代谢的影响及其与甲状腺癌的潜在关联。分析突出了与甲状腺功能障碍相关的特定细菌属、肠道微生物群在碘吸收中的作用，以及将失调与甲状腺疾病（如甲状腺功能减退、甲状腺功能亢进、桥本甲状腺炎和格雷夫斯病）联系起来的机制。此外，还研究了肠道微生物群作为诊断和个性化治疗生物标志物的潜力，以及益生菌和针对微生物群的治疗前景。该综述强调了进行更多研究以充分理解微生物群与甲状腺相互作用并开发适当疗法以改善临床结果和患者生活质量的重要性。
