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癌症诊疗纳米医学的进展

Advances in Nanomedicine for Cancer Theranostics.

作者信息

Mukherjee Sudip, Rengan Aravind Kumar, Patra Chitta Ranjan

机构信息

School of Biomedical Engineering IIT BHU, Hindu University Campus, Varanasi, Uttar Pradesh 221005, India.

Department of Biomedical Engineering, Indian Institute of Technology Hyderabad, Kandi, 502284 Sangareddy, Telangana, India.

出版信息

Biomed Mater. 2025 Jun 18;20(4). doi: 10.1088/1748-605X/addf26.

Abstract

Cancer is one of the foremost reasons for global death. According to estimates, around 19.3 million instances of cancer and over 10 million fatalities were documented in the year 2020, making it one of the leading causes of death across the globe. There are still restrictions due to the absence of effective early detection and inadequate conventional therapy, which has led to poor prognosis and survival rates. This is the case despite the fact that there have been breakthroughs in diagnosis and treatment. The science of nanomedicine has achieved considerable advancements in the realm of cancer theranostics. These advancements offer a number of distinct advantages, including tumor-targeting through the increased permeability and retention effect, biocompatibility, and small size. In light of the above, the purpose of the Focus Issue on 'Advances in Nanomedicine for Cancer Theranostics', was introduced to highlight new research on nanomedicine-based approaches to cancer treatment. These techniques include drug and gene delivery, bioimaging, biomarker identification, diagnosis, immunotherapy, biosensors, and other precision oncology strategies. For this Focus Issue, we invited front-line researchers and authors who contributed the original research papers and topical review articles. This editorial summarizes the published articles of this collection which includes eighteen research articles and eleven review articles.

摘要

癌症是全球死亡的主要原因之一。据估计,2020年记录了约1930万例癌症病例和超过1000万例死亡病例,使其成为全球主要死因之一。由于缺乏有效的早期检测手段和传统治疗方法不足,仍然存在限制,这导致了预后不良和生存率较低。尽管在诊断和治疗方面取得了突破,但情况依然如此。纳米医学在癌症诊疗领域取得了显著进展。这些进展具有许多独特优势,包括通过增强渗透和滞留效应实现肿瘤靶向、生物相容性和小尺寸。鉴于上述情况,推出了“癌症诊疗纳米医学进展”专题,以突出基于纳米医学的癌症治疗方法的新研究。这些技术包括药物和基因递送、生物成像、生物标志物识别、诊断、免疫疗法、生物传感器以及其他精准肿瘤学策略。对于本专题,我们邀请了一线研究人员和作者,他们贡献了原创研究论文和专题综述文章。这篇社论总结了本合集已发表的文章,其中包括18篇研究文章和11篇综述文章。

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