Pantothenic acid deficiency as a factor contributing to the development of hypertension.

In endemic pantothenic acid deficiency of some Japanese populations, increased occurrence of hypertension has been described. However, all attempts to produce hypertension experimentally by means of pantothenic acid deficiency have failed up to now. As a consequence, the observations made in Japan have largely been ignored. In this paper, pantothenic acid deficiency will be shown to be a factor in the experimental origin of hypertension due to adrenal regeneration.