Shen Yuan, Li Hong-Ying, Yang Qing-Qing, Zhang Ke, Liu Shu-Qing, Zhang Ning, Li Chen-Yu, Yu Shu-Guang, Xie Lu-Shuang, Wu Qiao-Feng
Acupuncture and Moxibustion School, Chengdu University of Traditional Chinese Medicine, Chengdu, 610075, Sichuan, China.
College of Basic Medicine, Chengdu University of Traditional Chinese Medicine, Chengdu, 610075, Sichuan, China.
Mol Neurobiol. 2025 Jun 18. doi: 10.1007/s12035-025-05147-2.
Alzheimer's disease (AD) is a prevalent neurodegenerative disorder characterized by significant impairment in energy metabolism. Our previous studies have demonstrated that moxibustion can ameliorate cognitive dysfunction by enhancing brain energy metabolism in individuals with AD, yet its fundamental mechanism remains incompletely understood. In this study, spatial transcriptomics, biochemical assays, and transmission electron microscopy were utilized to identify differentially expressed genes related to metabolism and their functions, as well as to determine the key metabolic genes influenced by moxibustion. Moxibustion significantly promote spatial learning and memory ability, while reducing the production of hippocampal pathological markers in APP/PS1 mice. Respiratory chain complex I may play an important role in regulating energy metabolism in the hippocampus during moxibustion. Additionally, moxibustion also elevated co-expression of PSD95/SYN, which exhibited a positive correlation with energy metabolism. Thus moxibustion has the potential to improve energy metabolism and synaptic plasticity in the hippocampus, subsequently ameliorating learning and memory impairments.
阿尔茨海默病（AD）是一种常见的神经退行性疾病，其特征是能量代谢严重受损。我们之前的研究表明，艾灸可以通过增强AD患者的脑能量代谢来改善认知功能障碍，但其基本机制仍未完全了解。在本研究中，利用空间转录组学、生化分析和透射电子显微镜来鉴定与代谢相关的差异表达基因及其功能，以及确定受艾灸影响的关键代谢基因。艾灸显著促进APP/PS1小鼠的空间学习和记忆能力，同时减少海马病理标志物的产生。呼吸链复合体I可能在艾灸过程中调节海马能量代谢方面发挥重要作用。此外，艾灸还提高了PSD95/SYN的共表达，其与能量代谢呈正相关。因此，艾灸有可能改善海马的能量代谢和突触可塑性，从而改善学习和记忆障碍。
