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Optimized intranasal delivery of segesterone acetate progestin to the brain using nanoemulsions and microemulsions.

作者信息

Peres Carina, Meirinho Sara, Ferreira da Silva Samille, Maocha Izamara, Chiangalala Anabela, Alves Ferreira Susana, Rodrigues Márcio, Zhang Shimin, Kumar Narender, Sitruk-Ware Regine, Caetano Oliveira Rui, Gaspar Carlos, Palmeira-de-Oliveira Ana, Palmeira-de-Oliveira Rita, Alves Gilberto, Baltazar Graça, Santos Adriana O

机构信息

RISE-Health, Faculty of Health Sciences, University of Beira Interior, Covilhã, 6200-506, Portugal.

BRIDGES - Biotechnology Research, Innovation and Design for Health Products, Polytechnic University of Guarda, Guarda, 6300-559, Portugal.

出版信息

Drug Deliv Transl Res. 2025 Jun 18. doi: 10.1007/s13346-025-01897-7.

DOI:10.1007/s13346-025-01897-7
PMID:40531370
Abstract
摘要

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本文引用的文献

[1]
Nanotechnological approaches for efficient N2B delivery: from small-molecule drugs to biopharmaceuticals.

Beilstein J Nanotechnol. 2024-11-12

[2]
Innovations in Nanoemulsion Technology: Enhancing Drug Delivery for Oral, Parenteral, and Ophthalmic Applications.

Pharmaceutics. 2024-10-17

[3]
Innovative Aqueous Nanoemulsion Prepared by Phase Inversion Emulsification with Exceptional Homogeneity.

Pharmaceutics. 2023-7-4

[4]
Nose-to-brain delivery of perampanel formulated in a self-microemulsifying drug delivery system improves anticonvulsant and anxiolytic activity in mice.

Int J Pharm. 2023-7-25

[5]
High-frequency repetitive magnetic stimulation rescues ischemia-injured neurons through modulation of glial-derived neurotrophic factor present in the astrocyte's secretome.

J Neurochem. 2023-3

[6]
Self-Emulsifying Drug Delivery Systems: An Alternative Approach to Improve Brain Bioavailability of Poorly Water-Soluble Drugs through Intranasal Administration.

Pharmaceutics. 2022-7-18

[7]
Intranasal delivery of lipid-based nanosystems as a promising approach for brain targeting of the new-generation antiepileptic drug perampanel.

Int J Pharm. 2022-6-25

[8]
Contraceptive drug, Nestorone, enhances stem cell-mediated remodeling of the stroke brain by dampening inflammation and rescuing mitochondria.

Free Radic Biol Med. 2022-4

[9]
Strategies to Improve Drug Strength in Nasal Preparations for Brain Delivery of Low Aqueous Solubility Drugs.

Pharmaceutics. 2022-3-8

[10]
In Vitro Ciliotoxicity and Cytotoxicity Testing of Repeated Chronic Exposure to Topical Nasal Formulations for Safety Studies.

Pharmaceutics. 2021-10-20

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