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Disrupted Osteoblastogenesis and Mitochondrial Remodeling in MSCs from Patients with Cushing's Syndrome.

作者信息

Di Vincenzo Mariangela, Campanati Anna, Ambrogini Patrizia, Del Vescovo Valerio, Marcheggiani Fabio, La Contana Alessandra, Marchi Saverio, Arnaldi Giorgio, Orciani Monia

机构信息

Department of Clinical and Molecular Sciences - Histology, Università Politecnica delle Marche, Ancona, Italy.

Department of Clinical and Molecular Sciences- Dermatologic Clinic, Università Politecnica delle Marche, Ancona, Italy.

出版信息

Stem Cell Rev Rep. 2025 Jun 18. doi: 10.1007/s12015-025-10913-9.

DOI:10.1007/s12015-025-10913-9
PMID:40531407
Abstract
摘要

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本文引用的文献

1
The multifaceted roles of mitochondria in osteoblasts: from energy production to mitochondrial-derived vesicle secretion.线粒体在成骨细胞中的多效性作用：从能量产生到线粒体衍生小泡的分泌。
J Bone Miner Res. 2024 Sep 2;39(9):1205-1214. doi: 10.1093/jbmr/zjae088.
2
Mitochondrial quality control and its role in osteoporosis.线粒体质量控制及其在骨质疏松症中的作用。
Front Endocrinol (Lausanne). 2023 Jan 30;14:1077058. doi: 10.3389/fendo.2023.1077058. eCollection 2023.
3
Mesenchymal Stem Cells Exposed to Persistently High Glucocorticoid Levels Develop Insulin-Resistance and Altered Lipolysis: A Promising Model to Study Cushing's Syndrome.
间质干细胞暴露于持续高水平的糖皮质激素下会产生胰岛素抵抗和脂解改变：研究库欣综合征的有前途模型。
Front Endocrinol (Lausanne). 2022 Feb 24;13:816229. doi: 10.3389/fendo.2022.816229. eCollection 2022.
4
Cushing Syndrome: The Role of MSCs in Wound Healing, Immunosuppression, Comorbidities, and Antioxidant Imbalance.库欣综合征：间充质干细胞在伤口愈合、免疫抑制、合并症及抗氧化失衡中的作用
Front Cell Dev Biol. 2019 Oct 9;7:227. doi: 10.3389/fcell.2019.00227. eCollection 2019.
5
Glucocorticoids suppress Wnt16 expression in osteoblasts in vitro and in vivo.糖皮质激素在体外和体内抑制成骨细胞中 Wnt16 的表达。
Sci Rep. 2018 Jun 7;8(1):8711. doi: 10.1038/s41598-018-26300-z.
6
Bone complications in patients with Cushing's syndrome: looking for clinical, biochemical, and genetic determinants.库欣综合征患者的骨骼并发症：探寻临床、生化及遗传决定因素
Osteoporos Int. 2014 Mar;25(3):913-21. doi: 10.1007/s00198-013-2520-5. Epub 2013 Oct 15.
7
Involvement of reactive oxygen species in osteoblastic differentiation of MC3T3-E1 cells accompanied by mitochondrial morphological dynamics.活性氧参与MC3T3-E1细胞成骨分化并伴有线粒体形态动力学变化。
Biomed Res. 2013 Jun;34(3):161-6. doi: 10.2220/biomedres.34.161.
8
Minimal criteria for defining multipotent mesenchymal stromal cells. The International Society for Cellular Therapy position statement.定义多能间充质基质细胞的最低标准。国际细胞治疗协会立场声明。
Cytotherapy. 2006;8(4):315-7. doi: 10.1080/14653240600855905.