Eyisoy Ömer Gökhan, Özgökçe Çağdaş, Taşdemir Ümit, Tekin Sinem, Demirci Oya
Zeynep Kamil Women and Children Diseases Training and Research Hospital Affiliated with the University of Health Sciences, Department of Obstetrics, Division of Perinatology - İstanbul, Turkey.
Haseki Training and Research Hospital Affiliated with the University of Health Sciences, Department of Obstetrics and Gynecology - İstanbul, Turkey.
Rev Assoc Med Bras (1992). 2025 Jun 16;71(5):e20242025. doi: 10.1590/1806-9282.20242025. eCollection 2025.
The aim of this study was to evaluate the role of substance P in pruritus in patients with intrahepatic cholestasis of pregnancy.
This prospective case-control study was conducted on 50 intrahepatic cholestasis of pregnancy patients and 30 gestational age-matched healthy pregnant women. The groups were compared in terms of serum substance P concentrations, and the correlation between these concentrations and self-reported itching was evaluated in patients with intrahepatic cholestasis of pregnancy.
Serum substance P concentrations were higher in patients with intrahepatic cholestasis of pregnancy than in the control group (960 vs. 611 ng/L; p=0.001). In intrahepatic cholestasis of pregnancy patients, there was a statistically significant positive correlation between the serum substance P concentration and both the Pruritus Severity Scale score (r=605, p<0.001) and the visual analog scale score for pruritus (r=483, p<0.001). On multivariable linear regression analysis, only the presence of intrahepatic cholestasis of pregnancy (pruritus) was statistically significantly associated with an increase in the serum substance P concentration (95%CI 145.06-558.16 ng/L; p=0.001).
The concentration of substance P is increased in patients with intrahepatic cholestasis of pregnancy and is correlated with the severity of the pruritus. While the precise role of elevated substance P levels in the etiology of intrahepatic cholestasis of pregnancy remains uncertain, it may contribute to the pathogenesis of pruritus through central and peripheral effects.
本研究旨在评估P物质在妊娠期肝内胆汁淤积症患者瘙痒中的作用。
本前瞻性病例对照研究对50例妊娠期肝内胆汁淤积症患者和30例孕周匹配的健康孕妇进行。比较两组血清P物质浓度，并评估妊娠期肝内胆汁淤积症患者这些浓度与自我报告瘙痒之间的相关性。
妊娠期肝内胆汁淤积症患者的血清P物质浓度高于对照组（960对611 ng/L；p=0.001）。在妊娠期肝内胆汁淤积症患者中，血清P物质浓度与瘙痒严重程度量表评分（r=605，p<0.001）和瘙痒视觉模拟量表评分均呈统计学显著正相关（r=483，p<0.001）。多变量线性回归分析显示，仅妊娠期肝内胆汁淤积症（瘙痒）的存在与血清P物质浓度升高具有统计学显著相关性（95%CI 145.06 - 558.16 ng/L；p=0.001）。
妊娠期肝内胆汁淤积症患者P物质浓度升高，且与瘙痒严重程度相关。虽然P物质水平升高在妊娠期肝内胆汁淤积症病因学中的确切作用仍不确定，但它可能通过中枢和外周效应促成瘙痒的发病机制。
