Alwhaibi Monira, Alhawassi Tariq M
Department of Clinical Pharmacy, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia.
PLoS One. 2025 Jun 18;20(6):e0325780. doi: 10.1371/journal.pone.0325780. eCollection 2025.
Adults with osteoarthritis are vulnerable to mental health disorders, which may have a significant impact on their Health-Related Quality of Life (HRQoL). Thus, the purpose of this study was to look at the relationship between anxiety and depression and HRQoL in adults with osteoarthritis.
Adult patients diagnosed with osteoarthritis who were 18 years of age or older were identified using data from the Medical Expenditure Panel Survey for the years 2018-2021. HRQoL was computed using the veteran's RAND 12-item health survey which has two domains the Physical and Mental Component Summary (PCS & MCS) ratings. The link between anxiety and depression and HRQoL in individuals with osteoarthritis was examined using multivariable linear regression after the adjustment for a variety of covariates.
Of the 3,658 individuals with osteoarthritis that were identified, 12.0% experienced depression, 12.5% had anxiety, and 9.9% had both illnesses. The PCS and MCS mean scores of the HRQoL were lowest for persons with comorbid depression and anxiety compared to adults with osteoarthritis only. Moreover, from the adjusted regression analysis, adults with osteoarthritis who had depression (MCS: adjusted β = -5.408, p < 0.001), anxiety (MCS: adjusted β = -3.485, p < 0.001), or both depression and anxiety (MCS: adjusted β = -10.348, p-value<0.0001) had significantly lower HRQoL MCS scores compared to those with osteoarthritis only. Those who were physically active and employed had notably better scores on the PCS and MCS than those who were not.
This nationally representative sample has shed light on the relationships between anxiety, depression, and a low HRQoL in adults with osteoarthritis. The study also revealed the impact of socioeconomic factors such as education level and income on HRQoL, and the benefits of employment and regular exercise. Importantly, the findings underscore the need for lifestyle modifications to reduce anxiety and depression in individuals with osteoarthritis. They also highlight the practical implications for healthcare planning and resource allocation, providing valuable insights for policymakers and healthcare professionals.
骨关节炎成人患者易患心理健康障碍，这可能对其健康相关生活质量（HRQoL）产生重大影响。因此，本研究旨在探讨骨关节炎成人患者焦虑、抑郁与HRQoL之间的关系。
利用2018 - 2021年医疗支出面板调查的数据，确定年龄在18岁及以上、被诊断为骨关节炎的成年患者。HRQoL采用退伍军人兰德12项健康调查进行计算，该调查有身体和心理成分总结（PCS和MCS）评分两个领域。在对各种协变量进行调整后，使用多变量线性回归分析骨关节炎患者焦虑、抑郁与HRQoL之间的联系。
在确定的3658例骨关节炎患者中，12.0%经历过抑郁，12.5%有焦虑，9.9%同时患有这两种疾病。与仅患骨关节炎的成年人相比，合并抑郁和焦虑的患者HRQoL的PCS和MCS平均得分最低。此外，经调整的回归分析显示，患有抑郁（MCS：调整后的β = -5.408，p < 0.001）、焦虑（MCS：调整后的β = -3.485，p < 0.001）或同时患有抑郁和焦虑（MCS：调整后的β = -10.348，p值<0.0001）的骨关节炎成年人，其HRQoL的MCS得分显著低于仅患骨关节炎的成年人。身体活跃且有工作的人在PCS和MCS上的得分明显高于不活跃和无工作的人。
这个具有全国代表性的样本揭示了骨关节炎成人患者焦虑、抑郁与低HRQoL之间的关系。该研究还揭示了教育水平和收入等社会经济因素对HRQoL的影响，以及就业和定期锻炼的益处。重要的是，研究结果强调了通过改变生活方式来减少骨关节炎患者焦虑和抑郁的必要性。它们还突出了对医疗保健规划和资源分配的实际意义，为政策制定者和医疗保健专业人员提供了有价值的见解。
