89例泪腺脱垂患者的临床病理特征

Clinicopathologic features of 89 patients with lacrimal gland prolapse.

作者信息

Qu Yu-Yao, Dong Le, Hu Ya-Guang, Gao Ning, Li Jing-Ming, Cheng Qiao-Chu, Gao Shan, Wei Ting, Ma Jian-Min, Zhang Wan-Hu

机构信息

Department of Ophthalmology, the First Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710061, Shaanxi Province, China.

Department of Ophthalmology, the Ninth Hospital of Xi'an, Xi'an 710054, Shaanxi Province, China.

出版信息

Int J Ophthalmol. 2025 Jun 18;18(6):1011-1015. doi: 10.18240/ijo.2025.06.06. eCollection 2025.

DOI:10.18240/ijo.2025.06.06

PMID:40534797

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12120461/

Abstract

AIM

To analyze the clinical and pathological features of 89 patients presenting as lacrimal gland prolapse (LGP).

METHODS

This retrospective study included 89 patients presenting as LGP. Magnetic resonance imaging (MRI) scan was performed for all patients. Pathology and immunohistochemical staining of prolapsed tissue were performed during the surgery. The histopathological subtype was obtained, and the related clinical manifestations of different subtype were marked.

RESULTS

Among the 89 patients involved, the histopathological subtype includes dacryoadenitis (43%; =38), focal lymphocytes infiltration (20%; =18), immunoglobulin G4 (IgG4)-related lacrimal gland inflammatory disease (15%; =13), lacrimal gland (13%; =12), and extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue (9%; =8). As for manifestations of different subtypes, eyelid swelling was found the most frequent of lymphocytes infiltration (44%, =8), and palpable lacrimal gland mass of dacryoadenitis (55%, =21). All the IgG4-related lacrimal gland inflammatory disease (100%, =13) and most dacryoadenitis (97%, =37) presented as bilateral.

CONCLUSION

LGP has the histopathological subtype most commonly as inflammation, followed by structural and lymphoproliferative changes. Most of patients present as eyelid swelling. Clinical manifestations can be significant to differentiate the diagnosis.

摘要

目的

分析89例以泪腺脱垂（LGP）就诊患者的临床及病理特征。

方法

本回顾性研究纳入89例以LGP就诊的患者。对所有患者进行磁共振成像（MRI）扫描。手术中对脱垂组织进行病理及免疫组化染色。获取组织病理学亚型，并标记不同亚型的相关临床表现。

结果

在纳入的89例患者中，组织病理学亚型包括泪腺炎（43%；n = 38）、局灶性淋巴细胞浸润（20%；n = 18）、免疫球蛋白G4（IgG4）相关泪腺炎性疾病（15%；n = 13）、泪腺肿瘤（13%；n = 12）以及黏膜相关淋巴组织结外边缘区B细胞淋巴瘤（9%；n = 8）。至于不同亚型的表现，淋巴细胞浸润型最常见的表现为眼睑肿胀（44%，n = 8），泪腺炎型最常见的表现为可触及泪腺肿块（55%，n = 21）。所有IgG4相关泪腺炎性疾病患者（100%，n = 13）及大多数泪腺炎患者（97%，n = 37）表现为双侧病变。