Berrandou Takiy-Eddine, Cordina-Duverger Emilie, Mulot Claire, Guizard Anne-Valérie, Schvartz Claire, Laurent-Puig Pierre, Zidane Monia, De Vathaire Florent, Guénel Pascal, Truong Thérèse
University Paris-Saclay, UVSQ, Inserm, Gustave Roussy, CESP, Team "Exposome and Heredity", Villejuif, France.
Quantitative Genetics and Genomics (QGG), Aarhus University, Aarhus, Denmark.
Front Genet. 2025 Jun 4;16:1539090. doi: 10.3389/fgene.2025.1539090. eCollection 2025.
Circadian rhythms are controlled by biological clocks regulated at the molecular level by a set of circadian genes operating through a negative feedback loop. These genes also regulate key biological processes, including cell proliferation, cell cycle, and apoptosis.
We investigated the role of circadian gene polymorphisms in the risk of differentiated thyroid cancer (DTC) and their interaction with DTC risk factors. Data were obtained from 463 DTC cases and 482 unrelated controls of European ancestry, selected from two population-based case-control studies conducted in France. Associations with 570 single nucleotide polymorphisms (SNPs) in 23 circadian genes were evaluated using multivariate logistic regression models. Gene- and pathway-level associations and gene-environment interactions were analyzed using the adaptive rank truncated product (ARTP) method.
We found no significant association between DTC risk and circadian gene polymorphisms at the SNP, gene, or pathway levels. However, we observed statistically significant interactions between smoking status and SNPs rs11204897 () and rs1012477 (), as well as with the gene and the overall circadian pathway. These results suggest that smoking status may modulate the association between DTC and polymorphisms in circadian genes. Further studies are needed to confirm these findings.
昼夜节律由生物钟控制，生物钟在分子水平上由一组通过负反馈回路运作的昼夜节律基因调节。这些基因还调节关键的生物学过程，包括细胞增殖、细胞周期和细胞凋亡。
我们研究了昼夜节律基因多态性在分化型甲状腺癌（DTC）风险中的作用及其与DTC风险因素的相互作用。数据来自463例DTC病例和482例欧洲血统的无关对照，这些数据选自法国进行的两项基于人群的病例对照研究。使用多变量逻辑回归模型评估了23个昼夜节律基因中570个单核苷酸多态性（SNP）的关联。使用自适应秩截尾乘积（ARTP）方法分析基因和通路水平的关联以及基因-环境相互作用。
我们在SNP、基因或通路水平上未发现DTC风险与昼夜节律基因多态性之间存在显著关联。然而，我们观察到吸烟状态与SNP rs11204897（）和rs1012477（）之间，以及与基因和整个昼夜节律通路之间存在统计学上的显著相互作用。这些结果表明吸烟状态可能调节DTC与昼夜节律基因多态性之间的关联。需要进一步的研究来证实这些发现。
