Delva P, De Gasperi M, Degan M, Covi G, Lechi A
Clin Sci (Lond). 1985 Nov;69(5):607-11. doi: 10.1042/cs0690607.
Outward bumetanide-sensitive Na+-K+ cotransport was studied in the erythrocytes of 51 subjects, 24 normotensive subjects and 27 hypertensive patients, matched for sex and age. Three kinetic parameters of this cation transport system were considered: velocity of efflux at saturating internal sodium (Nai) concentrations (Vmax.), apparent affinity for sodium (K 50%) and index of co-operativity among Nai sites (Hill's n). We correlated these values with clinical and laboratory data determined routinely in hypertension. There were no significant differences between normotensive and hypertensive subjects for the values considered and we did not find any significant correlations between co-transport and clinical data.
在51名受试者（24名血压正常者和27名高血压患者）的红细胞中研究了外向布美他尼敏感的钠钾协同转运，这些受试者在性别和年龄上相匹配。考虑了该阳离子转运系统的三个动力学参数：饱和细胞内钠（Nai）浓度下的外排速度（Vmax.）、对钠的表观亲和力（K 50%）以及Nai位点之间的协同指数（希尔系数n）。我们将这些值与高血压患者常规测定的临床和实验室数据进行了关联。对于所考虑的值，血压正常者和高血压患者之间没有显著差异，并且我们没有发现协同转运与临床数据之间存在任何显著相关性。
