Min Da-Yeong, Kim Song-Yi, Park Ji-Yeun, Kang Minseo, Kim Byoung-Soo
College of Korean Medicine, Daejeon University, Daejeon, Republic of Korea.
College of Korean Medicine, Gachon University, Seongnam, Republic of Korea.
Front Endocrinol (Lausanne). 2025 Jun 4;16:1456754. doi: 10.3389/fendo.2025.1456754. eCollection 2025.
Functional hypothalamic amenorrhea (FHA) is a complex clinical condition crucial to understand and treat due to its intricate etiology, difficulties in applying standard treatments, and significant long-term health effects. This study aimed to summarize and analyze the current research methodologies and findings from rodent models of FHA to provide insights for future investigations.
A literature search was conducted on EMBASE and MEDLINE up to September 23, 2022, using predefined search terms to target FHA-related studies in rodent models. This review focused on experimental studies involving rodent models of FHA, including related nonorganic disorders, such as primary ovarian insufficiency (POI) and polycystic ovary syndrome (PCOS). Data were independently collected by researchers, detailing animal models, FHA induction methods, experimental outcomes, and mechanistic exploration, with a synthesis of results comparing FHA with POI and PCOS.
Thirty articles (9 on FHA, 14 on POI, and 7 on PCOS) were analyzed, revealing diverse FHA induction methods, including dietary interventions and exercise, inconsistencies in estrous cycle monitoring, and varied focuses in mechanistic investigation. Some studies have emphasized hypothalamic-pituitary-adrenal axis dysfunction, whereas others have investigated ovarian abnormalities. Comparative analyses of POI and PCOS models identified research gaps and suggested future research directions.
The incorporation of consistent estrous cycle monitoring and biomarker measurements is crucial for the advancement of FHA research. Future studies should comprehensively investigate hormonal changes and explore potential therapeutic targets for ovarian inflammation and androgen involvement.
功能性下丘脑性闭经（FHA）是一种复杂的临床病症，因其病因复杂、标准治疗方法应用困难以及长期健康影响重大，所以对其进行理解和治疗至关重要。本研究旨在总结和分析当前FHA啮齿动物模型的研究方法和结果，为未来的研究提供见解。
截至2022年9月23日，在EMBASE和MEDLINE上进行了文献检索，使用预定义的检索词来查找啮齿动物模型中与FHA相关的研究。本综述重点关注涉及FHA啮齿动物模型的实验研究，包括相关的非器质性疾病，如原发性卵巢功能不全（POI）和多囊卵巢综合征（PCOS）。研究人员独立收集数据，详细记录动物模型、FHA诱导方法、实验结果和机制探索，并综合比较FHA与POI和PCOS的结果。
分析了30篇文章（9篇关于FHA，14篇关于POI，7篇关于PCOS），发现FHA诱导方法多样，包括饮食干预和运动，动情周期监测存在不一致性，机制研究重点各异。一些研究强调下丘脑 - 垂体 - 肾上腺轴功能障碍，而另一些研究则调查了卵巢异常。对POI和PCOS模型的比较分析确定了研究差距并提出了未来的研究方向。
采用一致的动情周期监测和生物标志物测量对于FHA研究的进展至关重要。未来的研究应全面调查激素变化，并探索卵巢炎症和雄激素参与的潜在治疗靶点。
