Nie Yuting, Gu Cheng, Wu Ruipeng, Gao Fulin, Zhang Le, Zhang Yamin
The Department of Neurology, Gansu Provincial Hospital, Lanzhou, China.
Front Aging Neurosci. 2025 Jun 4;17:1473135. doi: 10.3389/fnagi.2025.1473135. eCollection 2025.
BACKGROUND: Limited evidence exists regarding the relationship between calf circumference (CC) and global cognition in the Chinese population, with minimal research exploring potential sex disparities. Our goal was to investigate the correlation between CC and global cognition using data from the Chinese Longitudinal Healthy Longevity Survey (CLHLS), focusing specifically on sex variations. METHODS: The study participants were older adults who participated in the 2018 CLHLS survey. In this cross-sectional study, we employed multiple linear regression to examine the association between CC and global cognition. Smoothed curve fitting was used to explore the non-linear association between CC and global cognition. Furthermore, subgroup analyses were conducted to evaluate the reliability of the correlation between CC and global cognitive performance. RESULTS: In total, 12,102 older adults were included in the study. A positive correlation was found between global cognition and CC (β = 0.42, 95% CI = 0.3-0.54, < 0.001) after controlling for confounding factors. Further analysis revealed a non-linear relationship between CC and global cognitive performance. In the overall population, the inflection point for CC was 31 cm; a positive relationship was observed between CC and global cognition for CC values <31 cm (β = 0.177, 95% CI = 0.128-0.225, < 0.001); however, this relationship disappeared for CC values ≥ 31 cm (β: -0.009, 95% CI = -0.04 to 0.023, = 0.591). Furthermore, we identified sex-specific variations in the correlation between global cognitive performance and CC. Notably, among women with CC values <32 cm, a significant positive correlation was observed between CC and overall cognitive function. Conversely, for women with CC ≥ 32 cm, no significant association was found between CC and cognitive performance. Interestingly, no non-linear relationship was detected in males. CONCLUSION: This study demonstrated a non-linear relationship between CC and global cognition in older Chinese population. Furthermore, sex disparities are observed in the relationship between CC and global cognition, with a non-linear link evident in women but not in men. Older women with lower CC should actively participate in physical activity to maintain an appropriate CC and prevent cognitive decline.
背景：关于中国人群中 calf circumference（CC，小腿围）与整体认知之间的关系，现有证据有限，且极少有研究探讨潜在的性别差异。我们的目标是利用中国健康与养老追踪调查（CLHLS）的数据，研究 CC 与整体认知之间的相关性，特别关注性别差异。 方法：研究参与者为参加 2018 年 CLHLS 调查的老年人。在这项横断面研究中，我们采用多元线性回归来检验 CC 与整体认知之间的关联。使用平滑曲线拟合来探索 CC 与整体认知之间的非线性关联。此外，进行亚组分析以评估 CC 与整体认知表现之间相关性的可靠性。 结果：该研究共纳入 12,102 名老年人。在控制混杂因素后，发现整体认知与 CC 之间存在正相关（β = 0.42，95%CI = 0.3 - 0.54，P < 0.001）。进一步分析显示 CC 与整体认知表现之间存在非线性关系。在总体人群中，CC 的拐点为 31 厘米；当 CC 值 < 31 厘米时，观察到 CC 与整体认知之间存在正相关（β = 0.177，95%CI = 0.128 - 0.225，P < 0.001）；然而，当 CC 值≥31 厘米时，这种关系消失（β：-0.009，95%CI = -0.04 至 0.023，P = 0.591）。此外，我们发现了整体认知表现与 CC 之间相关性的性别特异性差异。值得注意的是，在 CC 值 < 32 厘米的女性中，观察到 CC 与整体认知功能之间存在显著正相关。相反，对于 CC≥32 厘米的女性，未发现 CC 与认知表现之间存在显著关联。有趣的是，在男性中未检测到非线性关系。 结论：本研究表明中国老年人群中 CC 与整体认知之间存在非线性关系。此外，在 CC 与整体认知之间的关系中观察到性别差异，女性存在明显的非线性联系，而男性则没有。CC 较低的老年女性应积极参与体育活动，以维持适当的 CC 并预防认知能力下降。
Cochrane Database Syst Rev. 2025-5-7
Cochrane Database Syst Rev. 2025-1-29
JMIR Public Health Surveill. 2024-12-16
Cochrane Database Syst Rev. 2021-12-7
Cochrane Database Syst Rev. 2025-6-16
Cochrane Database Syst Rev. 2025-6-9
J Parkinsons Dis. 2025-4-29
Aging Clin Exp Res. 2024-2-7
Redox Biol. 2024-4
BMC Public Health. 2023-3-11
Brain Plast. 2022-10-21
Zotero 插件
