Department of Geriatrics, Shanghai Ninth People's Hospital, Shanghai Jiaotong University School of Medicine, No.639, Zhizaoju Road, Shanghai, 200011, China.
Nursing Department, Shanghai Ninth People's Hospital, Shanghai Jiaotong University School of Medicine, No.639, Zhizaoju Road, Shanghai, 200011, China.
Eur Geriatr Med. 2022 Aug;13(4):771-787. doi: 10.1007/s41999-022-00661-1. Epub 2022 Jun 7.
The effects of sarcopenia on the older people are profound, increasing the risk of adverse outcomes for older patients. Although the substantial impact of sarcopenia on maintaining functional independence and adverse health outcomes has been described many times in the past, the link between sarcopenia and cognitive impairment in older adults remains lacking in evidence and controversial. Therefore, we conducted a comprehensive search of available national and international databases and carried out a meta-analysis to examine the association between sarcopenia in older people and cognitive impairment.
Relevant experiments had been recognized via looking out electronic databases and conference sessions. The present study included case-control, cohort, or cross-sectional studies of the association between sarcopenia and cognitive impairment in the older people.
The meta-analysis included 26 articles and 18,788 participants were involved after assessment of eligibility. The results of this meta-analysis showed that the risk of developing cognitive impairment was significantly higher in patients with sarcopenia than in those without sarcopenia [OR = 1.75; 95% CI = 1.57, 1.95; P < 0.00001], MMSE score of sarcopenia group was lower than that of non-sarcopenia group, the difference was statistically significant [OR = - 2.23; 95% CI = - 2.48, - 1.99; P < 0.00001].
Overall, this meta-analysis showed an association between sarcopenia and cognitive impairment in the older people, demonstrating a significant association between sarcopenia and cognitive impairment. This suggested that providing comprehensive sarcopenia screening and active prevention for the older people with cognitive decline has certain clinical value for improving the quality of life of the older people.
肌肉减少症对老年人的影响是深远的，增加了老年患者不良结局的风险。尽管肌肉减少症对维持功能独立性和不良健康结局的巨大影响在过去已经多次被描述，但肌肉减少症与老年人认知障碍之间的联系在证据和争议方面仍然缺乏。因此，我们进行了全面的搜索，以检查老年人中肌肉减少症和认知障碍之间的关联。
通过查找电子数据库和会议会议来识别相关实验。本研究包括了关于老年人肌肉减少症和认知障碍之间关联的病例对照、队列或横断面研究。
荟萃分析纳入了 26 篇文章，18788 名参与者在评估合格性后参与了研究。荟萃分析的结果表明，患有肌肉减少症的患者发生认知障碍的风险明显高于没有肌肉减少症的患者[OR=1.75；95%CI=1.57，1.95；P<0.00001]，肌肉减少症组的 MMSE 评分低于非肌肉减少症组，差异具有统计学意义[OR=-2.23；95%CI=-2.48，-1.99；P<0.00001]。
总的来说，这项荟萃分析显示了肌肉减少症与老年人认知障碍之间存在关联，表明肌肉减少症与认知障碍之间存在显著关联。这表明对有认知能力下降的老年人进行全面的肌肉减少症筛查和积极预防具有一定的临床价值，可以提高老年人的生活质量。
