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肝癌消融治疗的最新进展

Recent Advances in Ablative Therapies for HCC.

作者信息

Gupta Arun, Seth Raghav, Yadav Ajit, Kurki Vineeth

机构信息

Department of Interventional Radiology, Sir Ganga Ram Hospital, New Delhi, India.

出版信息

J Clin Exp Hepatol. 2025 Sep-Oct;15(5):102592. doi: 10.1016/j.jceh.2025.102592. Epub 2025 May 17.

DOI:10.1016/j.jceh.2025.102592
PMID:40535845
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12173004/
Abstract

Hepatocellular carcinoma (HCC) is the sixth most common cause of cancer worldwide and ranks third in terms of cancer related mortality. The management options for earlystage HCC include surgical resection, liver transplantation and percutaneous imageguided ablation. However, majority of the patients are not appropriate candidates for liver transplantation or surgical resection. Thus, image-guided tumour ablation has evolved as an accepted curative management option for these patients, according to most of the HCC management guidelines, due to its less invasive nature and proven efficacy. The aim of this article is to review the currently available data and the latest techniques for percutaneous ablation of HCC.

摘要

肝细胞癌(HCC)是全球第六大常见癌症病因,在癌症相关死亡率方面排名第三。早期HCC的治疗选择包括手术切除、肝移植和经皮影像引导下消融。然而,大多数患者并不适合肝移植或手术切除。因此,根据大多数HCC治疗指南,影像引导下肿瘤消融因其侵入性较小且疗效已得到证实,已成为这些患者可接受的根治性治疗选择。本文旨在综述目前可用的数据以及HCC经皮消融的最新技术。

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本文引用的文献

1
Microwave ablation single-needle radiofrequency ablation for the treatment of HCC up to 4 cm: A randomized-controlled trial.微波消融与单针射频消融治疗直径达4厘米的肝细胞癌:一项随机对照试验。
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Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries.2022 年全球癌症统计数据:全球 185 个国家和地区 36 种癌症的发病率和死亡率全球估计数。
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Integration of Ethanol and the Immune Modulator Curcumin for Immunoablation of Hepatocellular Carcinoma.乙醇与免疫调节剂姜黄素联合用于肝癌的免疫消融。
J Vasc Interv Radiol. 2024 Jul;35(7):1033-1042.e11. doi: 10.1016/j.jvir.2024.03.014. Epub 2024 Mar 19.
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2023 Update of Indian National Association for Study of the Liver Consensus on Management of Intermediate and Advanced Hepatocellular Carcinoma: The Puri III Recommendations.印度国家肝脏研究协会关于中晚期肝细胞癌管理共识的2023年更新:普里III建议
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Combined Ultrasound and Computed Tomography Guidance in Radiofrequency Ablation for Hepatocellular Carcinoma Reduces Local Recurrence Rate.超声与计算机断层扫描联合引导下的肝细胞癌射频消融术可降低局部复发率。
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Atezolizumab plus bevacizumab versus active surveillance in patients with resected or ablated high-risk hepatocellular carcinoma (IMbrave050): a randomised, open-label, multicentre, phase 3 trial.阿替利珠单抗联合贝伐珠单抗对比主动监测用于治疗接受手术切除或消融治疗的高风险肝细胞癌患者(IMbrave050):一项随机、开放标签、多中心、III 期临床试验。
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8
Irreversible electroporation of hepatocellular carcinoma and colorectal cancer liver metastases: A nationwide multicenter study with short- and long-term follow-up.不可逆电穿孔治疗肝细胞癌和结直肠癌肝转移瘤:一项具有短期和长期随访的全国多中心研究。
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9
No-Touch Radiofrequency Ablation for Early Hepatocellular Carcinoma: 2023 Korean Society of Image-Guided Tumor Ablation Guidelines.无接触射频消融治疗早期肝细胞癌:2023 年韩国影像引导肿瘤消融治疗指南。
Korean J Radiol. 2023 Aug;24(8):719-728. doi: 10.3348/kjr.2023.0423.
10
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