Shi Fu-Dong, Yong V Wee
Department of Neurology, China National Clinical Research Center for Neurological Diseases, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
Department of Neurology, Tianjin Medical University General Hospital, Tianjin, China.
Science. 2025 Jun 19;388(6753):eadx0043. doi: 10.1126/science.adx0043.
The brain's response to injury includes the activation of intrinsic microglia and the influx of leukocytes, collectively constituting neuroinflammation, the "flame" of the brain. Although details differ and matter, neuroinflammation exacerbating neurodegeneration has similarities across multiple sclerosis and other neurological disorders, such as stroke and neurodegenerative diseases. Thus, lessons from successful disease-modifying therapies in multiple sclerosis may provide insights into strategies for modulating neuroinflammation and reducing neural injury in other neurological conditions. In this Review, we discuss these lessons and potential strategies for counteracting neuroinflammation, including taming the microglia-orchestrated brain immune responses that contribute to progressing neuropathology.
大脑对损伤的反应包括固有小胶质细胞的激活和白细胞的涌入，共同构成神经炎症，即大脑的“火焰”。尽管具体细节有所不同且很重要，但加剧神经退行性变的神经炎症在多发性硬化症和其他神经系统疾病（如中风和神经退行性疾病）中存在相似之处。因此，多发性硬化症中成功的疾病修饰疗法的经验教训可能为调节神经炎症和减少其他神经疾病中的神经损伤的策略提供见解。在本综述中，我们讨论了这些经验教训以及对抗神经炎症的潜在策略，包括驯服导致神经病理学进展的小胶质细胞协调的大脑免疫反应。
