This scoping review comprehensively evaluates the role of radiofrequency microneedling (RFM) in facial rejuvenation, focusing on its applications across specific anatomical regions, integration with transdermal drug delivery and outcome assessments. Searching on PubMed, Web of Science and Embase indicates that RFM is multifunctional in the treatment of cheeks, periorbital regions, mandible, lower face, neck and photoaging. The combination of RFM with agents like poly-L-lactic acid, polynucleotides, platelet-rich plasma and trichloroacetic acid further enhances treatment outcomes, promoting collagen synthesis and skin repair. The outcome assessment used to assess the efficacy and safety of RFM treatment were concluded, which were categorized into subjective (patient satisfaction) and objective (clinical evaluations) measures, provide a comprehensive understanding of efficacy and guide personalized treatment strategies. This review highlights RFM's significant potential as a versatile and effective tool in facial rejuvenation.Level of Evidence I This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors   www.springer.com/00266 .