Wang Chen, Chen Dongfeng, Yin Yonghui, Liu Xiujuan, Liu Yi, Li Xiaoyun, Kong Chang, Zhao Quanlin
The First Clinical Medical College, Shandong University of Traditional Chinese Medicine, Jinan, Shandong, China.
Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan, Shandong, China.
Ren Fail. 2025 Dec;47(1):2511275. doi: 10.1080/0886022X.2025.2511275. Epub 2025 Jun 19.
Diabetic kidney disease (DKD) is a common chronic microvascular complication of diabetes and the leading cause of end-stage renal disease. Its pathogenesis is closely linked to cellular senescence. Studies have shown that cellular senescence drives DKD progression multiple mechanisms, including tubulointerstitial fibrosis, glomerulosclerosis, oxidative stress, and aberrant AMP-activated protein kinase (AMPK)/mammalian target of rapamycin (mTOR) signaling. However, there remains a lack of specific therapeutic targets or effective drugs for DKD treatment. Traditional Chinese medicine (TCM), characterized by its multidimensional, multi-target, significant efficacy, and fewer adverse effects, has shown unique advantages in DKD prevention and treatment. This article systematically examines the role of cellular senescence in DKD pathogenesis and, guided by TCM theory, explores how TCM may regulate cellular senescence to mitigate DKD, offering novel perspectives for enhancing clinical management of this condition.
糖尿病肾病（DKD）是糖尿病常见的慢性微血管并发症，也是终末期肾病的主要原因。其发病机制与细胞衰老密切相关。研究表明，细胞衰老通过多种机制推动DKD进展，包括肾小管间质纤维化、肾小球硬化、氧化应激以及异常的腺苷酸活化蛋白激酶（AMPK）/雷帕霉素靶蛋白（mTOR）信号传导。然而，DKD治疗仍缺乏特异性治疗靶点或有效药物。以多维度、多靶点、疗效显著、副作用少为特点的传统中医（TCM）在DKD防治中显示出独特优势。本文系统研究了细胞衰老在DKD发病机制中的作用，并以中医理论为指导，探讨中医如何调节细胞衰老以减轻DKD，为改善该疾病的临床管理提供新的视角。
