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经腹腔镜肝段Ⅷ亚段切除术及胆囊切除术诊断的原发性肝和胆囊非霍奇金淋巴瘤：1例罕见病例报告

Primary Non-Hodgkin Lymphoma of the Liver and Gallbladder Diagnosed by Laparoscopic Segment 8 Subsegmentectomy and Cholecystectomy: A Rare Case Report.

作者信息

Nitta Toshikatsu, Ishii Masatsugu, Taki Masataka, Kubo Ryutaro, Sada Akitada, Takeshita Atsushi, Ishibashi Takashi

机构信息

Division of Surgery Gastroenterological Center, Medico Shunju Shiroyama Hospital, Osaka, Japan.

Department of Pathology, Medico Shunju Shiroyama Hospital, Osaka, Japan.

出版信息

J Investig Med High Impact Case Rep. 2025 Jan-Dec;13:23247096251348909. doi: 10.1177/23247096251348909. Epub 2025 Jun 20.

DOI:10.1177/23247096251348909
PMID:40538186
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12181694/
Abstract

A 71-year-old Japanese woman presented to our hospital to consult for a gallbladder polyp detected on a routine ultrasound in 2024. We found a sized-up gallbladder polyp and a liver tumor. She underwent laparoscopic segment 8 subsegmentectomy and cholecystectomy for suspected malignancy. Pathology revealed aggressive follicular lymphoma of the liver and gallbladder. Immunohistochemical staining was positive for CD10, CD20, CD23, CD79a, BCL-2, and BCL-6, and negative for CD3, CD5, and cyclin-D1. Primary hepatic lymphoma and gallbladder polyp are accidental, and diagnosis is difficult without tissue biopsy or specimens. Laparoscopic hepatectomy facilitates accurate diagnosis and early postoperative recovery, enabling rapid chemotherapy administration.

摘要

一名71岁的日本女性因2024年常规超声检查发现胆囊息肉前来我院咨询。我们发现胆囊息肉增大以及肝脏有肿瘤。她因怀疑恶性肿瘤接受了腹腔镜下肝段8亚段切除术和胆囊切除术。病理显示肝脏和胆囊为侵袭性滤泡性淋巴瘤。免疫组化染色CD10、CD20、CD23、CD79a、BCL-2和BCL-6呈阳性，CD3、CD5和细胞周期蛋白D1呈阴性。原发性肝脏淋巴瘤和胆囊息肉是偶然发现的，没有组织活检或标本很难诊断。腹腔镜肝切除术有助于准确诊断和术后早期恢复，能够快速进行化疗。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/983b/12181694/812367bfbf04/10.1177_23247096251348909-fig7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/983b/12181694/0f452a4a9bbe/10.1177_23247096251348909-fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/983b/12181694/c37de586c64d/10.1177_23247096251348909-fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/983b/12181694/232b022198c1/10.1177_23247096251348909-fig3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/983b/12181694/e7cc9dfb2366/10.1177_23247096251348909-fig4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/983b/12181694/046286ab3c32/10.1177_23247096251348909-fig5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/983b/12181694/729b4e87fc48/10.1177_23247096251348909-fig6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/983b/12181694/812367bfbf04/10.1177_23247096251348909-fig7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/983b/12181694/0f452a4a9bbe/10.1177_23247096251348909-fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/983b/12181694/c37de586c64d/10.1177_23247096251348909-fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/983b/12181694/232b022198c1/10.1177_23247096251348909-fig3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/983b/12181694/e7cc9dfb2366/10.1177_23247096251348909-fig4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/983b/12181694/046286ab3c32/10.1177_23247096251348909-fig5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/983b/12181694/729b4e87fc48/10.1177_23247096251348909-fig6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/983b/12181694/812367bfbf04/10.1177_23247096251348909-fig7.jpg

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本文引用的文献

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Diffuse Large B-cell Lymphoma with Severe Lactic Acidosis and Liver Failure: A Case Report and Literature Review.伴严重乳酸酸中毒和肝衰竭的弥漫性大B细胞淋巴瘤：一例报告及文献复习
Intern Med. 2025 May 15;64(10):1534-1541. doi: 10.2169/internalmedicine.4450-24. Epub 2024 Oct 11.
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CT and MR imaging characteristics of primary hepatic lymphoma.原发性肝淋巴瘤的CT和MR成像特征
Discov Oncol. 2024 Sep 11;15(1):428. doi: 10.1007/s12672-024-01316-2.
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Follicular Lymphoma Treated with First-Line Immunochemotherapy: A Review of PET/CT in Patients Who Did Not Achieve a Complete Metabolic Response in the GALLIUM Study.
一线免疫化疗治疗滤泡性淋巴瘤：在 GALLIUM 研究中未达到完全代谢缓解的患者的 PET/CT 回顾。
J Nucl Med. 2022 Aug;63(8):1149-1154. doi: 10.2967/jnumed.121.262869. Epub 2021 Dec 2.
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Diagnostic approach in hepatic lymphoma: radiological imaging findings and literature review.肝淋巴瘤的诊断方法：影像学表现及文献复习。
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Follicular lymphoma: 2020 update on diagnosis and management.滤泡性淋巴瘤：诊断与管理的 2020 年更新。
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