高敏C反应蛋白/高密度脂蛋白、动脉粥样硬化指数和非高密度脂蛋白胆固醇与慢性阻塞性肺疾病的关联：一项横断面美国国家健康与营养检查调查研究

Association of hs-CRP/HDL, AIP and NHHR with chronic obstructive pulmonary disease: a cross-sectional NHANES study.

作者信息

Qin Jiangyue, Ran Bi, Wu Yanqiu, Xu Dan, Liu Lian, Li Diandian, Chen Lei, Wen Fuqiang

机构信息

Department of Respiratory and Critical Care Medicine, West China Hospital and Division of Pulmonary Diseases, State Key Laboratory of Biotherapy of China, Sichuan University, Chengdu, Sichuan, China.

Department of General Practice, General Practice Medical Center, West China Hospital, Sichuan University, Chengdu, China.

出版信息

Ann Med. 2025 Dec;57(1):2522317. doi: 10.1080/07853890.2025.2522317. Epub 2025 Jun 20.

DOI:10.1080/07853890.2025.2522317

PMID:40538265

Abstract

BACKGROUND

Inflammation and dyslipidemia have been proven to be associated with chronic obstructive pulmonary disease (COPD). The purpose of this study was to evaluate the relationships between hS-CRP/HDL, AIP, NHHR and COPD.

MATERIALS AND METHODS

The data was obtained from the National Health and Nutrition Examination Survey. Participants were classified into two groups based on self-reported COPD diagnosis. The hS-CRP/HDL, AIP and NHHR were evaluated for their potential correlation with COPD using the univariate and multivariable logistic regression models. Subsequently, restricted cubic spline (RCS) model was used to further explore the associations between hS-CRP/HDL, AIP, NHHR and COPD. Finally, subgroup analysis and interaction tests were applied.

RESULTS

10419 participants were included, and 1168 of them were self-reported COPD. lg(hs-CRP/HDL) and AIP were statistically significantly elevated in the COPD group compared to those in non-COPD group, while NHHR was not significantly different between the two groups. In a multivariate logistic regression model that adjusted for all relevant factors, there was a 64% increase in the prevalence of COPD for every unit rise in hs-CRP/HDL (OR 1.64 [CI 1.31-2.05]). A significant positive association between hs-CRP/HDL and COPD was observed in most subgroups. However, the AIP and NHHR were not associated with COPD after adjusted for all relevant factors. RCS model supported a positive linear association of hs-CRP/HDL with COPD , and no linear or non-linear association of AIP, or NHHR and COPD.

CONCLUSIONS

The study suggests elevated hs-CRP/HDL may related to COPD, suggesting its potential as diagnostic marker for COPD.

摘要

背景

炎症和血脂异常已被证明与慢性阻塞性肺疾病（COPD）有关。本研究的目的是评估高敏C反应蛋白/高密度脂蛋白（hS-CRP/HDL）、动脉粥样硬化指数（AIP）、非高密度脂蛋白胆固醇与高密度脂蛋白胆固醇比值（NHHR）与COPD之间的关系。

材料与方法

数据来源于美国国家健康与营养检查调查。根据自我报告的COPD诊断结果，将参与者分为两组。使用单变量和多变量逻辑回归模型评估hS-CRP/HDL、AIP和NHHR与COPD的潜在相关性。随后，使用受限立方样条（RCS）模型进一步探讨hS-CRP/HDL、AIP、NHHR与COPD之间的关联。最后，进行亚组分析和交互作用检验。

结果

纳入10419名参与者，其中1168人自我报告患有COPD。与非COPD组相比，COPD组的lg(hs-CRP/HDL)和AIP在统计学上显著升高，而两组之间的NHHR没有显著差异。在调整了所有相关因素的多变量逻辑回归模型中，hs-CRP/HDL每升高一个单位，COPD患病率增加64%（比值比1.64[置信区间1.31-2.05]）。在大多数亚组中观察到hs-CRP/HDL与COPD之间存在显著正相关。然而，在调整了所有相关因素后，AIP和NHHR与COPD无关。RCS模型支持hs-CRP/HDL与COPD呈正线性关联，而AIP、NHHR与COPD无线性或非线性关联。