Chang Liangzheng, Li Lu, Han Yuling, Cheng Hui, Yang Liuliu
State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Disease, Haihe Laboratory of Cell Ecosystem, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, China.
Tianjin Institute of Health Science, Tianjin, China.
Cell Prolif. 2025 Jun;58(6):e13806. doi: 10.1111/cpr.13806. Epub 2025 Jan 26.
Organoid technology, as a revolutionary biomedical tool, has shown immense potential in haematological research in recent years. By using three-dimensional (3D) cell culture systems constructed from pluripotent stem cells (PSCs) or adult stem cells (ASCs), organoids can highly mimic the characteristics of in vivo organs, thereby offering significant potential for investigating human organ development, disease processes and treatment strategies. This review introduces the development of organoids and focuses on their progress in haematological research, including haematopoietic-related organoids, immune-related organoids and organoids used for studying blood system diseases. It discusses the prospects, challenges and future outlook of organoids in the field of haematology. This review aims to provide the latest advancements and future directions of organoid technology in haematological research, offering references and insights into further exploration in this field.
类器官技术作为一种革命性的生物医学工具，近年来在血液学研究中展现出了巨大潜力。通过使用由多能干细胞（PSC）或成体干细胞（ASC）构建的三维（3D）细胞培养系统，类器官能够高度模拟体内器官的特征，从而为研究人类器官发育、疾病过程及治疗策略提供了巨大潜力。本综述介绍了类器官的发展，并重点关注其在血液学研究中的进展，包括造血相关类器官、免疫相关类器官以及用于研究血液系统疾病的类器官。它讨论了类器官在血液学领域的前景、挑战和未来展望。本综述旨在提供类器官技术在血液学研究中的最新进展和未来方向，为该领域的进一步探索提供参考和见解。
