Mohammed Stephanie, Sundaram Venkatesan, Cockburn Brian N, Motilal Shastri, Ottey Sasha, Azziz Ricardo
Dept. of Preclinical Sciences, Faculty of Medical Sciences, The University of the West Indies at St Augustine, Republic of Trinidad and Tobago.
Dept. of Physics, Faculty of Science and Technology, The University of the West Indies, St. Augustine, Republic of Trinidad and Tobago.
Womens Health Rep (New Rochelle). 2025 Apr 24;6(1):493-503. doi: 10.1089/whr.2025.0008. eCollection 2025.
Polycystic Ovary Syndrome (PCOS) affects 8%-13% of reproductive-age women globally, with comorbidities including obesity, insulin resistance, type 2 diabetes, and psychological disorders. Socioeconomic status (SES) significantly impacts health outcomes.
A community-based, pilot study was conducted in Trinidad among females aged 18-45 years, representing diverse ethnicities and SES. Participants underwent a standardized history and physical exam. Clinical hyperandrogenism (HIR) was assessed using the modified Ferriman-Gallwey scale (HIR ≥6), menstrual dysfunction (MD) as <9 cycles/year, depression Beck's Inventory, overall health using SF-12 v1, and daytime somnolence with the Epworth Sleepiness Scale. Data analysis included descriptive statistics, analysis of variance, and multinomial logistic regression adjusting for confounders.
Among 250 participants (mean age 31.6 ± 7.9 years), we classified 200 with clinical presentations, which included: no MD or HIR (56.7%), MD only (14.4%), HIR only (21.9%), and MD+HIR (7%). Age, income, and education were significantly correlated with clinical presentation. Older age reduced the risk of HIR (mean difference = 4.507, = 0.004) and MD+HIR (mean difference = 9.063, < 0.001). Income (OR = 0.37, 95% CI: 0.16-0.87, = 0.022) reduced MD odds. Self-reported infertility was associated with MD (odds ratio [OR] = 0.27, 95% confidence interval [CI]: 0.11-0.65, = 0.006). MD+HIR correlated with severe depression (OR = 5.96, 95% CI: 1.62-21.90, = 0.007). Mental health scores (SF-12 MCS) were lower in women with MD+HIR (mean difference = -11.477, = 0.005).
Seven percent of women in this sample showed probable PCOS based on clinical manifestations, with SES impacting quality of life, mental health, and sleep. Higher income reduced MD and MD+HIR risk, while infertility increased MD risk and severe depression was linked to MD+HIR.
多囊卵巢综合征（PCOS）影响着全球8%-13%的育龄妇女，其合并症包括肥胖、胰岛素抵抗、2型糖尿病和心理障碍。社会经济地位（SES）对健康结果有显著影响。
在特立尼达对18-45岁的女性进行了一项基于社区的试点研究，这些女性代表了不同的种族和社会经济地位。参与者接受了标准化的病史和体格检查。使用改良的费里曼-盖尔维量表（HIR≥6）评估临床高雄激素血症（HIR），月经功能障碍（MD）定义为每年月经周期少于9次，使用贝克抑郁量表评估抑郁，使用SF-12 v1评估总体健康状况，使用爱泼华嗜睡量表评估日间嗜睡情况。数据分析包括描述性统计、方差分析以及对混杂因素进行调整的多项逻辑回归分析。
在250名参与者（平均年龄31.6±7.9岁）中，我们对200名有临床表现的参与者进行了分类，其中包括：无MD或HIR（56.7%）、仅MD（14.4%）、仅HIR（21.9%）以及MD+HIR（7%）。年龄、收入和教育程度与临床表现显著相关。年龄较大降低了HIR（平均差异=4.507，P=0.004）和MD+HIR（平均差异=9.063，P<0.001）的风险。收入（OR=0.37，95%CI：0.16-0.87，P=0.022）降低了MD的几率。自我报告的不孕与MD相关（优势比[OR]=0.27，95%置信区间[CI]：0.11-0.65，P=0.006）。MD+HIR与严重抑郁相关（OR=5.96，95%CI：1.62-21.90，P=0.007）。MD+HIR女性的心理健康评分（SF-12 MCS）较低（平均差异=-11.477，P=0.005）。
基于临床表现，该样本中有7%的女性可能患有PCOS，社会经济地位影响生活质量、心理健康和睡眠。较高收入降低了MD和MD+HIR的风险，而不孕增加了MD风险，严重抑郁与MD+HIR相关。
