Peng Shiyu, Tian Shuxin
Department of Gastroenterology, the First Affiliated Hospital of Medical College, Shihezi University, Shihezi, Xinjiang, China.
Front Oncol. 2025 Jun 5;15:1590544. doi: 10.3389/fonc.2025.1590544. eCollection 2025.
We report a rare case of intestinal-type gastric cancer combined with submucosal ectopic gastric glands in a patient without Helicobacter pylori (HP) infection. A 55-year-old female presented for a routine health check-up. Gastroscopy revealed a lesion approximately 2.0 cm in size, classified as type O-IIa+IIc, located on the posterior wall of the upper gastric body. Endoscopic biopsy indicated high-grade intraepithelial neoplasia, which promoted endoscopic submucosal dissection (ESD). Pathological examination confirmed mucosal adenocarcinoma with submucosal ectopic gastric glands. Given the association of such lesions with gastric cancer, careful diagnosis and treatment are essential. The patient remained disease-free without recurrence during a 2-year follow-up period.
我们报告一例罕见的肠型胃癌合并黏膜下异位胃腺病例，该患者无幽门螺杆菌（HP）感染。一名55岁女性因常规健康检查就诊。胃镜检查发现一个大小约2.0 cm的病变，分类为O-IIa+IIc型，位于胃体上部后壁。内镜活检显示高级别上皮内瘤变，遂行内镜黏膜下剥离术（ESD）。病理检查确诊为黏膜腺癌合并黏膜下异位胃腺。鉴于此类病变与胃癌的关联，仔细的诊断和治疗至关重要。在2年的随访期内，患者无疾病复发。
