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一名患有镰状细胞性状的非裔美国患者在接受尿路上皮癌治疗期间,聚乙二醇化非格司亭引发阴茎异常勃起的罕见病例

A Rare Presentation of Priapism From Pegylated Filgrastim During Treatment of Urothelial Cancer in an African-American Patient With Sickle Cell Trait.

作者信息

Kathuria-Prakash Nikhita, Damron Leland, Hernandez Sandy C, Hart Steven D, Drakaki Alexandra

机构信息

Hematology and Medical Oncology, University of California Los Angeles David Geffen School of Medicine, Los Angeles, USA.

Medicine, University of California Los Angeles David Geffen School of Medicine, Los Angeles, USA.

出版信息

Cureus. 2025 May 20;17(5):e84492. doi: 10.7759/cureus.84492. eCollection 2025 May.

Abstract

Priapism is a complication of sickle cell disease resulting in organ-threatening vaso-occlusive crisis and has been reported rarely in patients with sickle cell trait. We report a case of a patient with urothelial carcinoma undergoing chemotherapy and growth factor support with pegylated filgrastim with stuttering priapism triggered by pegylated filgrastim. This is the first case reported, to our knowledge, of stuttering priapism triggered by pegylated filgrastim, and we hope to raise awareness of this potentially organ-threatening complication in this vulnerable population.

摘要

阴茎异常勃起是镰状细胞病的一种并发症,可导致危及器官的血管闭塞性危机,而在镰状细胞性状患者中鲜有报道。我们报告一例患有尿路上皮癌的患者,在接受化疗并使用聚乙二醇化非格司亭进行生长因子支持治疗时,出现了由聚乙二醇化非格司亭引发的间歇性阴茎异常勃起。据我们所知,这是首例由聚乙二醇化非格司亭引发的间歇性阴茎异常勃起病例,我们希望提高对这一在该脆弱人群中可能危及器官的并发症的认识。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5be5/12178588/a371eec01d45/cureus-0017-00000084492-i01.jpg

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