He Yu, Zhao Ying, Chang Qiang, Li Ting, Zeng Zhaowei
Department of Plastic and Reconstruction Surgery, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China.
Department of Plastic Surgery, the First Affiliated Hospital of Jinan University, Jinan University, Guangzhou, 510632, China.
J Mater Chem B. 2025 Jul 16;13(28):8470-8482. doi: 10.1039/d5tb00007f.
Accelerating wound healing poses a significant challenge in clinical practice, necessitating the exploration of innovative strategies. The development of biomaterials with tissue repair and regenerative properties represents a forefront approach to addressing this challenge; however, the functional characteristics and application methods of these materials remain limited. In this context, a novel bioactive micro carrier (Bio-MC) was developed from egg white hydrogel microspheres (EWMs) which served as a bio-niche incorporating adipose-derived stem cells (ADSCs). This formulation capitalizes on the intrinsic tissue reparative capabilities of stem cells, allowing for the sustained release of multiple growth factors. These factors, paracrine signaling, promote the proliferation and migration of neighboring cells, thereby creating an environment that supports wound healing. Upon application to wound sites, Bio-MCs exhibited significant effectiveness in enhancing the healing process by promoting tissue regeneration, increasing collagen deposition, and facilitating vascularization. The paracrine signaling mediated by Bio-MCs has the potential to exert lasting beneficial effects on cells in a comprehensive and physiologically relevant manner. In comparison to conventional growth factor treatments, the Bio-MC offers enhanced application versatility and functional attributes, indicating substantial promise in the field of tissue repair and regeneration and representing a noteworthy advancement in the clinical management of wounds.
在临床实践中，加速伤口愈合是一项重大挑战，因此有必要探索创新策略。开发具有组织修复和再生特性的生物材料是应对这一挑战的前沿方法；然而，这些材料的功能特性和应用方法仍然有限。在此背景下，一种新型生物活性微载体（Bio-MC）由蛋清水凝胶微球（EWMs）制成，EWMs作为一种生物龛，包裹脂肪来源干细胞（ADSCs）。这种制剂利用了干细胞固有的组织修复能力，实现多种生长因子的持续释放。这些因子通过旁分泌信号促进邻近细胞的增殖和迁移，从而营造支持伤口愈合的环境。将Bio-MCs应用于伤口部位后，通过促进组织再生、增加胶原蛋白沉积和促进血管生成，在加速愈合过程中显示出显著效果。Bio-MCs介导的旁分泌信号有可能以全面且与生理相关的方式对细胞产生持久有益影响。与传统生长因子治疗相比，Bio-MC具有更高的应用通用性和功能特性，在组织修复和再生领域展现出巨大潜力，是伤口临床管理方面的一项重大进展。
