Tomida M, Koyama H, Ono T
J Cell Physiol. 1977 May;91(2):323-8. doi: 10.1002/jcp.1040910217.
Calf serum as well as rat and mouse sera has a factor that stimulates hyaluronic acid synthesis in cultured rat fibroblasts. Such a factor was partially purified from calf serum and characterized. It has a molecular weight of approximately 150,000. The activity of the factor is lost by treatment with pronase and by periodate oxidation. It is suggested, therefore, that the factor is a glycoprotein. Its susceptibility to alpha-mannosidase and affinity for Con A-Sepharose may suggest that the factor contains a mannose residue(s) which is essential for the activity to induce hyaluronic acid synthesis.
小牛血清以及大鼠和小鼠血清中有一种能刺激培养的大鼠成纤维细胞合成透明质酸的因子。这种因子已从小牛血清中部分纯化并进行了特性鉴定。它的分子量约为150,000。该因子的活性经链霉蛋白酶处理和高碘酸盐氧化后丧失。因此，推测该因子是一种糖蛋白。它对α-甘露糖苷酶的敏感性以及对刀豆球蛋白A-琼脂糖的亲和力可能表明该因子含有一个（些）对诱导透明质酸合成活性至关重要的甘露糖残基。
