Koçer Ali Mert, Hondur Gözde, Uzel Mehmet Murat, Kösekahya Pınar, Uzun Aysel, Yalçınsoy Kübra Özdemir
Ulucanlar Eye Training and Research Hospital, Ankara, Turkey.
Int Ophthalmol. 2025 Jun 20;45(1):252. doi: 10.1007/s10792-025-03631-1.
This study aimed to evaluate the short-term effects of topical latanoprostene bunod on corneal and anterior segment parameters in patients with primary open-angle glaucoma (POAG).
A prospective, cross-sectional study was conducted on 30 eyes of 30 patients with POAG. All participants received topical latanoprostene bunod monotherapy. Corneal and anterior segment parameters, including keratometry, corneal thickness, endothelial cell characteristics, and corneal densitometry, were measured before and approximately after one month of treatment using the Pentacam HR and non-contact specular microscopy. Statistical analysis was performed to compare pre- and post-treatment measurements.
No significant changes were observed in corneal keratometry, endothelial cell density, hexagonality, or anterior chamber parameters including anterior chamber angle, depth, and volume following treatment (p > 0.05 for all). Although reductions in central corneal thickness and thinnest corneal thickness were noted, these changes were not statistically significant (p > 0.05 for both). A significant decrease in densitometric parameters was observed in most corneal zones after treatment, including anterior, central, posterior, and total thickness measurements (p < 0.05 for all). In contrast, no significant change was found in the peripheral 10-12 mm zones (p > 0.05 for all).
Short-term use of latanoprostene bunod reduced corneal densitometry values, suggesting improved corneal transparency without significantly affecting corneal thickness, endothelial cell characteristics, or anterior segment parameters. Further long-term studies with larger sample sizes are needed to evaluate its prolonged effects on corneal health.
本研究旨在评估局部使用布诺前列素拉坦对原发性开角型青光眼（POAG）患者角膜和眼前节参数的短期影响。
对30例POAG患者的30只眼进行了一项前瞻性横断面研究。所有参与者均接受局部布诺前列素拉坦单药治疗。使用Pentacam HR和非接触式角膜内皮显微镜在治疗前和治疗约1个月后测量角膜和眼前节参数，包括角膜曲率、角膜厚度、内皮细胞特征和角膜密度测定。进行统计分析以比较治疗前后的测量值。
治疗后角膜曲率、内皮细胞密度、六角形细胞比例或眼前节参数（包括前房角、深度和容积）均未观察到显著变化（所有p>0.05）。尽管中央角膜厚度和最薄角膜厚度有所降低，但这些变化无统计学意义（两者p>0.05）。治疗后大多数角膜区域的密度测定参数显著降低，包括前、中央、后和总厚度测量值（所有p<0.05）。相比之下，周边10-12毫米区域未发现显著变化（所有p>0.05）。
短期使用布诺前列素拉坦可降低角膜密度测定值，提示角膜透明度提高，而对角膜厚度、内皮细胞特征或眼前节参数无显著影响。需要进一步进行更大样本量的长期研究来评估其对角膜健康的长期影响。
