Farrell Jennifer M, Brown Sam P
Center for Microbial Dynamics and Infection, Georgia Institute of Technology, Atlanta, Georgia, USA.
School of Biological Sciences, Georgia Institute of Technology, Atlanta, Georgia, USA.
Microbiology (Reading). 2025 Jun;171(6). doi: 10.1099/mic.0.001567.
In this primer, we will review the key distinctions between acute and chronic infections, between mono- and polymicrobial infections and how these distinctions work together to generate the growing crisis of chronic polymicrobial infections. Chronic (non-resolving) infections place a large and growing burden on human health, globally. Following an introduction to the basic properties of chronic polymicrobial infections, we will use an ecological and evolutionary perspective to help outline a research agenda for this field, flagging both challenges and opportunities for improved infection prevention, diagnosis and treatment.
在本入门指南中，我们将回顾急性感染与慢性感染之间、单微生物感染与多微生物感染之间的关键区别，以及这些区别如何共同作用，导致慢性多微生物感染这一日益严重的危机。慢性（未愈）感染在全球范围内给人类健康带来了巨大且不断增加的负担。在介绍慢性多微生物感染的基本特性之后，我们将从生态和进化的角度，帮助勾勒该领域的研究议程，指出在改善感染预防、诊断和治疗方面所面临的挑战与机遇。
