Coulthard M G
Early Hum Dev. 1985 Sep;11(3-4):281-92. doi: 10.1016/0378-3782(85)90082-9.
Glomerular filtration rate (GFR) was measured in 39 healthy infants (gestation 27-40 weeks, birthweight 0.68-3.71 kg) by prolonged inulin infusion between 2 and 63 days of age. Absolute GFR showed a logarithmic rise with conceptional age (gestational plus postnatal age) which was independent of postnatal age. GFR per kilogram showed a slow rise with gestational age, and a rapid rise with increasing postnatal age which was shown to be due to a temporary cessation of growth rather than a true acceleration in renal maturation. GFR per unit surface area showed similar, but steeper rises. Formulae were constructed to predict GFR in the first month of life from postnatal age (PA), weight and birthweight (BW); (GFR = (0.24 BW + 0.18 PA + 0.45) X weight), or from conceptional age (CA); (GFR = 100.0618 CA-1.859). 95% of the predictions fell within 66 and 151%, and 58 and 172% of the measured values, respectively. Data from 14 studies were expressed in the same format where possible. The agreement between the reported data and this study was close. Apparent contradictions between these studies had been largely due to their different forms of presentation.
在39名健康婴儿（胎龄27 - 40周，出生体重0.68 - 3.71千克）出生后2至63天期间，通过长时间输注菊粉来测量肾小球滤过率（GFR）。绝对GFR随孕龄（孕周加出生后年龄）呈对数上升，且与出生后年龄无关。每千克体重的GFR随孕周缓慢上升，随出生后年龄增加而快速上升，这表明是由于生长暂时停止而非肾脏成熟真正加速所致。每单位表面积的GFR呈现相似但更陡峭的上升。构建了公式以根据出生后年龄（PA）、体重和出生体重（BW）预测出生后第一个月的GFR；（GFR =（0.24 BW + 0.18 PA + 0.45）×体重），或根据孕龄（CA）预测；（GFR = 100.0618 CA - 1.859）。95%的预测值分别落在测量值的66%至151%以及58%至172%范围内。在可能的情况下，将14项研究的数据以相同格式表示。报告的数据与本研究之间的一致性很高。这些研究之间明显的矛盾主要是由于它们不同的呈现形式。
