Chen Chenglong, Wang Juan, Xu Jiuhui, Shi Qianyu, Thong Hao-Cheng, Liu Yi-Xuan, Yu Han, Zhang Xinyue, Li Chao, Li Qian, Li Shun, Gong Wen, Ma Xin, Su Chang, Xie Yige, Yao Fang-Zhou, Wang Ke, Zhang Shujun, Wang Shidong
Department of Orthopedics, Beijing Jishuitan Hospital, Capital Medical University, Beijing 100035, China.
Department of Stomatology, Beijing Jishuitan Hospital, Capital Medical University, Beijing 100035, China.
Nano Lett. 2025 Jul 2;25(26):10270-10278. doi: 10.1021/acs.nanolett.4c06494. Epub 2025 Jun 20.
Osteosarcoma (OS) constitutes a severe malignant disorder affecting bone tissue and poses a significant global public health risk. Here, we introduce an injectable, synergistic chemopiezodynamic therapy utilizing tin selenide (SnSe) two-dimensional nanosheets, which generate reactive oxygen species (ROS) to target OS effectively. We observed clear antitumor effects in OS following treatment with SnSe. These effects are primarily attributed to Sn/Se vacancy-driven free radical catalysis, known as chemodynamic therapy, and are further augmented by ultrasonic vibrations for ultrasound-triggered piezocatalysis (piezodynamic therapy). Additionally, SnSe induced apoptosis and autophagy in OS cells while demonstrating satisfactory histocompatibility in mouse models. Comprehensive assessments at both cellular level and xenograft models confirm that injectable SnSe nanosheets achieve cytotoxicity and tumor eradication via the synergistic effects of chemo-piezocatalysis. This research paves the way for the customized development of advanced nanocatalysts with integrated synergistic catalysis, offering promising avenues for enhanced therapeutic strategies in oncology.
骨肉瘤（OS）是一种影响骨组织的严重恶性疾病，对全球公共卫生构成重大风险。在此，我们介绍一种利用硒化锡（SnSe）二维纳米片的可注射协同化学-压电动力疗法，该疗法可产生活性氧（ROS）以有效靶向骨肉瘤。在用SnSe治疗骨肉瘤后，我们观察到明显的抗肿瘤效果。这些效果主要归因于Sn/Se空位驱动的自由基催化，即化学动力疗法，并且通过超声振动进一步增强以实现超声触发的压电催化（压电动力疗法）。此外，SnSe诱导骨肉瘤细胞凋亡和自噬，同时在小鼠模型中表现出令人满意的组织相容性。在细胞水平和异种移植模型上的综合评估证实，可注射的SnSe纳米片通过化学-压电催化的协同作用实现细胞毒性和肿瘤根除。这项研究为定制开发具有集成协同催化作用的先进纳米催化剂铺平了道路，为肿瘤学中增强治疗策略提供了有希望的途径。
