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瘦素“管弦乐队”中的新成员：阿片促黑皮质素原/神经肽Y神经元调节食欲与肥胖。

New players in the leptin orchestra: PNOC/NPY neurons tune appetite and obesity.

作者信息

Lavoie Olivier, Michael Natalie J, Caron Alexandre

机构信息

Faculty of Pharmacy, Université Laval, Quebec City, QC, Canada; Quebec Heart and Lung Institute, Quebec City, QC, Canada.

Faculty of Pharmacy, Université Laval, Quebec City, QC, Canada; Quebec Heart and Lung Institute, Quebec City, QC, Canada.

出版信息

Neuron. 2025 Jun 18;113(12):1855-1857. doi: 10.1016/j.neuron.2025.05.026.

DOI:10.1016/j.neuron.2025.05.026
PMID:40541330
Abstract

Leptin regulates energy balance through the brain, yet its key neuronal targets remain unclear. Solheim et al. identify hypothalamic GABAergic PNOC/NPY neurons as mediators of leptin's anorectic effects, advancing our understanding of neurocircuits linking adiposity signals to feeding control.

摘要

瘦素通过大脑调节能量平衡，但其关键的神经元靶点仍不清楚。索尔海姆等人确定下丘脑γ-氨基丁酸能PNOC/神经肽Y神经元是瘦素厌食作用的介质，增进了我们对将肥胖信号与进食控制联系起来的神经回路的理解。

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