Bellon Margot, Salamanca Elaine, Friedman Steven, Chan Michael, Shirazian Taraneh
Drexel University College of Medicine, Philadelphia, PA, 19104, USA.
Center for Fibroid Care, Department of Obstetrics and Gynecology, NYU Langone Health, New York, NY, USA.
Reprod Sci. 2025 Jun 20. doi: 10.1007/s43032-025-01904-9.
The objective of this prospective, longitudinal cohort study was to evaluate the pilot effects of a 24-month exercise and nutrition intervention, called the Lifestyle Intervention for Fibroid Elimination Program (LIFE), at NYU Langone Health's Center for Fibroid Care. Specifically, we evaluate the impact on quality of life (QOL), symptom severity (SS), and clinical lab markers in 22 fibroid patients. Patients who underwent a procedure within 3 months of the start of the LIFE Program and completed up to 12 months of the program were included in this study. Participants were excluded if currently pregnant, postmenopausal, or had dietary restrictions or physical constraints that prevented them from participating fully in the intervention. This intervention required participants to follow a prescribed nutrition and exercise regimen for up to 12 months and attend at least 2 office visits with a physician. Participants also completed two quality of life questionnaires and regular ultrasound imaging. The demographic breakdown of our study cohort was 63.6% Black and 18.2% Hispanic/LatinX. A clinically meaningful improvement in QOL and symptom severity was found within the first year of the LIFE program. The QOL sub-scale scores that showed the greatest improvement were concern and energy/mood. Vitamin D lab values also showed a clinically meaningful improvement. The LIFE Program was associated with a reduction in symptom burden and an improvement in quality of life up to 12 months after a procedural fibroid intervention, yielding insight into how a lifestyle intervention may be an effective adjunct in improving patient quality of life.
这项前瞻性纵向队列研究的目的是评估纽约大学朗格尼健康中心纤维瘤护理中心一项为期24个月的运动与营养干预措施（称为纤维瘤消除生活方式干预计划，即LIFE）的初步效果。具体而言，我们评估了该干预措施对22名纤维瘤患者生活质量（QOL）、症状严重程度（SS）和临床实验室指标的影响。在LIFE计划开始后3个月内接受过手术且完成了长达12个月该计划的患者被纳入本研究。如果患者目前怀孕、已绝经，或有饮食限制或身体限制而无法充分参与干预，则被排除在外。该干预措施要求参与者遵循规定的营养和运动方案长达12个月，并至少看两次医生门诊。参与者还完成了两份生活质量问卷和定期超声成像检查。我们研究队列的人口统计学分类为63.6%为黑人，18.2%为西班牙裔/拉丁裔。在LIFE计划的第一年，发现生活质量和症状严重程度有了具有临床意义的改善。改善最为显著的生活质量子量表分数是担忧以及精力/情绪。维生素D实验室值也有了具有临床意义的改善。LIFE计划与在纤维瘤手术后长达12个月内症状负担的减轻和生活质量的改善相关，这为生活方式干预如何可能成为改善患者生活质量的有效辅助手段提供了见解。
