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鼻咽部神经鞘瘤罕见表现的诊断与治疗:一例报告

Diagnosis and management of an unusual presentation of schwannoma in nasopharynx: a case report.

作者信息

Kavarthapu Srilatha, Saha Kaushik, Singh Vasudha, Nalamolu Venkata Krishna Sundeep, Singh Manish

机构信息

Manipal Tata Medical College, Baridih, Jamshedpur, Jharkhand, India.

Department of Pathology, Tata Main Hospital, Jamshedpur, Jharkhand, India.

出版信息

J Med Case Rep. 2025 Jun 20;19(1):289. doi: 10.1186/s13256-025-05132-2.

Abstract

BACKGROUND

Schwann cells are responsible for producing the myelin sheath that surrounds the axons in the peripheral nervous system. Benign tumors that originate from Schwann cells are called schwannomas or neurilemmomas. These tumors typically present as slow-growing, solitary, encapsulated masses, often associated with nerve trunks. Schwannomas are relatively rare, with 25-45% of cases occurring in the head and neck region.

CASE PRESENTATION

This report aims to describe the presentations, work-up, and treatment of a 38-year-old Indian female patient with head and neck schwannoma in an atypical location. It was an incidental swelling noted during functional endoscopic sinus surgery. The tumor was found to be originating from the junction of the posterior and lateral pharyngeal wall near the lower edge of the torus tubarius on the left side. Complete surgical excision of the tumor was done in this case with no reported recurrence at 6 months' follow-up. The final diagnosis was made on the basis of histopathology and immunohistochemistry findings.

CONCLUSION

Histopathology should serve as the foundation for a definitive diagnosis. Tumor removal can be carried out using minimally invasive surgery through the endoscopic approach, resulting in fewer complications and a lowered risk of morbidity.

摘要

背景

施万细胞负责产生围绕周围神经系统轴突的髓鞘。起源于施万细胞的良性肿瘤称为施万瘤或神经鞘瘤。这些肿瘤通常表现为生长缓慢、孤立的、有包膜的肿块,常与神经干相关。施万瘤相对罕见,25% - 45%的病例发生在头颈部区域。

病例介绍

本报告旨在描述一名38岁印度女性头颈部非典型部位施万瘤的临床表现、检查及治疗情况。该肿瘤是在功能性鼻内镜鼻窦手术中偶然发现的肿胀。发现肿瘤起源于左侧咽鼓管圆枕下缘附近的咽后壁与侧壁交界处。本病例对肿瘤进行了完整的手术切除,随访6个月未见复发报告。最终诊断基于组织病理学和免疫组化结果。

结论

组织病理学应作为明确诊断的基础。可通过内镜入路采用微创手术进行肿瘤切除,从而减少并发症并降低发病风险。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ec17/12181876/9b4cca9b1602/13256_2025_5132_Fig2_HTML.jpg

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