Cho David J, Bokhoor Pooya I, Dermenchyan Anna, Brownell Nicholas, Delavin Nina Lou, Furlong Sean, Hoo Juyea, Tibbe Tristan, Chen Lucia Y, Vangala Sitaram, Waterman Benjamin A, Han Maria, Fonarow Gregg C, Hsue Priscilla Y, Chima-Melton Chidinma
Department of Medicine, Division of Cardiology, UCLA Health, Los Angeles, California, United States.
Department of Medicine, Division of Cardiology, UCLA Health, Los Angeles, California, United States.
JACC Adv. 2025 Jun 20;4(7):101879. doi: 10.1016/j.jacadv.2025.101879.
Adherence to guideline-directed medical therapy (GDMT) is central to quality-improvement programs, although the impact of financial incentive programs has been mixed.
Assess the impact of a cardiovascular population health initiative that integrates financial incentives, robust data infrastructure, and electronic health record clinical decision support on improving GDMT for cardiovascular disease (CVD).
The program was implemented across 15 ambulatory clinics with 54 cardiologists in an academic health system. Individualized CVD patient panels were created for each provider, and providers received quarterly performance and incentive reports. Quality metrics included antiplatelet and statin or proprotein convertase subtilisin/kexin type 9 inhibitor therapy for atherosclerotic cardiovascular disease prevention, blood pressure control, and GDMT for heart failure with reduced ejection fraction (HFrEF; specified beta blockers; ACEI, ARB, or ARNI; mineralocorticoid receptor antagonist). An interrupted time series analysis evaluated monthly, 1-year, and 2-year changes in the odds of adhering to each specific metric associated with the implementation of the cardiovascular population health program.
After the intervention, the composite HFrEF therapy metric improved significantly (2-year odds ratio [OR]: 2.285; 95% confidence interval [CI]: 1.653-3.158; P < 0.001). Individual metrics also improved, including mineralocorticoid receptor antagonist (2-year OR: 3.039; 95% CI: 2.520-3.663; P < 0.001); specified beta blockers (2-year OR: 1.430; 95% CI: 1.129-1.810; P = 0.003); angiotensin-converting enzyme inhibitor, angiotensin receptor blocker, or angiotensin receptor-neprilysin inhibitor therapy for HFrEF (2-year OR: 1.228; 95% CI: 1.001-1.505; P = 0.049); statin or proprotein convertase subtilisin/kexin type 9 inhibitor therapy for atherosclerotic cardiovascular disease (2-year OR: 1.146; 95% CI: 1.092-1.202; P < 0.001); and blood pressure control (2-year OR: 1.496; 95% CI: 1.444-1.550; P < 0.001).
Our program was associated with sustained improvements in GDMT adherence for CVD. It may serve as a scalable model for enhancing the quality of cardiovascular care.
遵循指南指导的药物治疗(GDMT)是质量改进计划的核心,尽管经济激励计划的影响好坏参半。
评估一项心血管人群健康倡议的影响,该倡议整合了经济激励、强大的数据基础设施和电子健康记录临床决策支持,以改善心血管疾病(CVD)的GDMT。
该计划在一个学术医疗系统的15个门诊诊所和54名心脏病专家中实施。为每个提供者创建了个性化的CVD患者小组,提供者每季度收到绩效和激励报告。质量指标包括用于预防动脉粥样硬化性心血管疾病的抗血小板和他汀类药物或前蛋白转化酶枯草溶菌素/kexin 9型抑制剂治疗、血压控制以及射血分数降低的心力衰竭(HFrEF;特定的β受体阻滞剂;ACEI、ARB或ARNI;盐皮质激素受体拮抗剂)的GDMT。中断时间序列分析评估了与心血管人群健康计划实施相关的每个特定指标依从性几率的月度、1年和2年变化。
干预后,HFrEF综合治疗指标显著改善(2年优势比[OR]:2.285;95%置信区间[CI]:1.653 - 3.158;P < 0.001)。个别指标也有所改善,包括盐皮质激素受体拮抗剂(2年OR:3.039;95% CI:2.520 - 3.663;P < 0.001);特定的β受体阻滞剂(2年OR:1.430;95% CI:1.129 - 1.810;P = 0.003);用于HFrEF的血管紧张素转换酶抑制剂、血管紧张素受体阻滞剂或血管紧张素受体脑啡肽酶抑制剂治疗(2年OR:1.228;95% CI:1.001 - 1.505;P = 0.049);用于动脉粥样硬化性心血管疾病的他汀类药物或前蛋白转化酶枯草溶菌素/kexin 9型抑制剂治疗(2年OR:1.146;95% CI:1.092 - 1.202;P < 0.001);以及血压控制(2年OR:1.496;95% CI:1.444 - 1.550;P < 0.001)。
我们的计划与CVD的GDMT依从性持续改善相关。它可以作为提高心血管护理质量的可扩展模型。