Goyal Priyanshi, Malviya Rishabha, Awasthi Rajendra, Warsi Musarrat Husain
Department of Pharmacy, School of Medical and Allied Sciences, Galgotias University, Greater Noida, Uttar Pradesh, India.
Department of Pharmacy, School of Medical and Allied Sciences, Galgotias University, Greater Noida, Uttar Pradesh, India.
Int J Biol Macromol. 2025 Aug;319(Pt 2):145406. doi: 10.1016/j.ijbiomac.2025.145406. Epub 2025 Jun 19.
This study aimed to prepare acrylamide graft copolymers of cellulose crystals from jute fiber. The prepared copolymer was analyzed to establish its pharmaceutical applications. Prepared cellulose crystals were grafted by microwave irradiation and characterized for water absorbency, chemical resistance, and temperature sensitivity behaviours. Bovine serum albumin was loaded into grafted cellulose crystals using the swelling-diffusion method. 3 factorial design was followed for formulation optimization. The results of micrometric studies of cellulose crystals revealed that the crystals were free flowing, had good flowability, and had a good percentage of water absorbency (94.0 ± 0.73 at 25 °C) and chemical resistance (94.6 ± 0.81 at 25 °C). The chemical resistance and water absorbency increased with an increase in temperature. The native jute fiber had a smooth and fibrous surface, whereas cellulose crystals had a rough surface. The chemical resistance (97.9 ± 0.88 to 98.4 ± 0.85 in 0.1 N HCl pH 1.2 and 97.7 ± 0.83 to 98.2 ± 0.85 in PBS pH 7.4) and water absorbency (95.3 ± 0.76 to 96.0 ± 0.84 in 0.1 N HCl pH 1.2 and 94.1 ± 0.83 to 95.6 ± 0.79 in PBS pH 7.4) of the acrylamide-grafted copolymer were enhanced relative to treated jute fiber. Acrylamide-grafted copolymers demonstrated high drug loading (75.5 ± 0.29 to 71.0 ± 0.41 %) and prolonged drug release (98.96 ± 4.10 to 99.13 ± 3.47) over a period of 24 h in comparison to the cellulose crystals which achieved 91.93 ± 2.82 % release within 6 h. Formulations followed Hixon-Crowel kinetic model of drug release. The results demonstrated that acrylamide-grafted cellulose crystals had enhanced water absorption, chemical resistance, temperature sensitivity, and prolonged drug release, indicating potential applications in pharmaceuticals.
本研究旨在制备黄麻纤维纤维素晶体的丙烯酰胺接枝共聚物。对制备的共聚物进行分析以确定其药物应用。通过微波辐射对接枝制备的纤维素晶体进行接枝，并对其吸水性、耐化学性和温度敏感性行为进行表征。采用溶胀扩散法将牛血清白蛋白负载到接枝纤维素晶体中。采用三因素设计进行配方优化。纤维素晶体的微观研究结果表明，晶体流动性良好，具有良好的流动性，且具有较高的吸水率（25℃时为94.0±0.73）和耐化学性（25℃时为94.6±0.81）。耐化学性和吸水率随温度升高而增加。天然黄麻纤维表面光滑且呈纤维状，而纤维素晶体表面粗糙。与处理过的黄麻纤维相比，丙烯酰胺接枝共聚物的耐化学性（在0.1N HCl pH 1.2中为97.9±0.88至98.4±0.85，在PBS pH 7.4中为97.7±0.83至98.2±0.85）和吸水率（在0.1N HCl pH 1.2中为95.3±0.76至96.0±0.84，在PBS pH 7.4中为94.1±0.83至95.6±0.79）有所提高。与在6小时内实现91.93±2.82%释放的纤维素晶体相比，丙烯酰胺接枝共聚物在24小时内表现出高载药量（75.5±0.29至71.0±0.41%）和延长的药物释放（98.96±4.10至99.13±3.47）。制剂遵循药物释放的希克森-克劳韦尔动力学模型。结果表明，丙烯酰胺接枝纤维素晶体具有增强的吸水性、耐化学性、温度敏感性和延长的药物释放，表明其在药物领域具有潜在应用。
