Wang Yulin, Liao Wanchen, Wang Lei, Li Jun, Huang Dongqing, Cheng Weibin, Tian Junzhang, Luan Ping
The Affiliated Guangdong Second Provincial General Hospital of Jinan University, Guangzhou, 510317, China.
School of Basic Medical Sciences, Shenzhen University, Shenzhen, 518060, China.
Mol Psychiatry. 2025 Jun 21. doi: 10.1038/s41380-025-03081-2.
Alzheimer's disease (AD) is a progressive neurodegenerative disease which is continually increasing in prevalence and is attracting more and more attention. Based on the traditional diagnostic framework, imaging biomarkers have shown great prospect in diagnosis. Positron emission tomography (PET) imaging, as a novel biomarker of AD, evaluates the progress and changes at the molecular level and develops many radiotracers corresponding to the hallmark biological targets. Compounds labeled with radioactive elements are transported to specific regions or combine with specific substances such as amyloid β(Aβ), paired helical filaments (PHFs) and neurofibrillary tangles (NFTs), which makes different radioactive uptake in different brain regions of AD. This review will set forth F-FDG PET imaging, Aβ-PET imaging, Tau-PET imaging, neuroinflammatory PET imaging, neurotransmitter PET imaging and some other emerging PET imaging. In clinical practices, PET performed with other medical imaging tools shows a great prospect.
阿尔茨海默病（AD）是一种进行性神经退行性疾病，其患病率持续上升，正吸引着越来越多的关注。基于传统诊断框架，影像生物标志物在诊断方面已展现出巨大前景。正电子发射断层扫描（PET）成像作为AD的一种新型生物标志物，在分子水平评估病情进展与变化，并研发出许多对应标志性生物学靶点的放射性示踪剂。标记有放射性元素的化合物被转运至特定区域或与特定物质如淀粉样β蛋白（Aβ）、双螺旋丝（PHF）和神经原纤维缠结（NFT）相结合，这使得AD患者不同脑区出现不同的放射性摄取。本综述将阐述¹⁸F - FDG PET成像、Aβ - PET成像、Tau - PET成像、神经炎症PET成像、神经递质PET成像以及其他一些新兴的PET成像。在临床实践中，PET与其他医学影像工具联合使用展现出巨大前景。
