Li Dan, Feng Pei, Wang Yaru, Yang Junzheng
Nursing School, North Henan Medical University, Xinxiang, 453003, China.
Guangdong nephrotic drug Engineering Technology Research Center, Institute of Consun Co. for Chinese Medicine in Kidney Diseases, Guangzhou, 510530, China.
Mol Biol Rep. 2025 Jun 21;52(1):622. doi: 10.1007/s11033-025-10727-5.
Kidney diseases are prevalent worldwide and represent a significant cause of mortality, posing a substantial threat to public health. Exosomes are a type of nanoscale lipid-encapsulated structure with a diameter of 30-200 nm. They contain a variety of substances including proteins, mRNA, and microRNA. It has been demonstrated that they fulfill a significant function in the regulation of intercellular communication. The inherent characteristics of exosomes, including their ability to regulate complex intracellular pathways, suggest a significant therapeutic potential in the treatment of numerous diseases, including renal diseases. The present review aims to provide a comprehensive overview of the application of exosome in kidney diseases, exploring the underlying mechanisms that underpin their function. Furthermore, it examines the limitations of current applications and potential solutions to address these challenges. It is hoped that this review will contribute to the advancement of exosome research and application in the field of kidney diseases.
肾脏疾病在全球范围内普遍存在，是导致死亡的重要原因，对公众健康构成重大威胁。外泌体是一种直径为30 - 200纳米的纳米级脂质包裹结构。它们包含多种物质，包括蛋白质、信使核糖核酸（mRNA）和微小核糖核酸（microRNA）。已经证明它们在细胞间通讯的调节中发挥着重要作用。外泌体的固有特性，包括其调节复杂细胞内途径的能力，表明其在治疗包括肾脏疾病在内的多种疾病方面具有巨大的治疗潜力。本综述旨在全面概述外泌体在肾脏疾病中的应用，探讨其功能背后的潜在机制。此外，它还研究了当前应用的局限性以及应对这些挑战的潜在解决方案。希望本综述将有助于推动外泌体在肾脏疾病领域的研究和应用。
