非BRCA基因突变患者中种族和族裔与降低风险的乳房切除术的关联。
The association of race and ethnicity with risk-reducing mastectomies in patients with non-BRCA mutations.
作者信息
Ntowe Koumani W, Thomas Samantha M, Dalton Juliet C, Olunuga Ebunoluwa, Wang Ton, Chiba Akiko, Plichta Jennifer K
机构信息
Department of Surgery, Duke University Medical Center, 2301 Erwin Rd, Durham, NC, 27707, USA.
Duke Cancer Institute, Duke University, 10 Bryan Searle Drive, Durham, NC, 27710, USA; Department of Biostatistics and Bioinformatics, Duke University, 40 Duke Medicine Circle, Durham, NC, 27710, USA.
出版信息
Am J Surg. 2025 Sep;247:116485. doi: 10.1016/j.amjsurg.2025.116485. Epub 2025 Jun 18.
INTRODUCTION
We compared rates of risk reducing mastectomies (RRM) in patients with breast cancer (BC)-related pathogenic variants.
METHODS
Female patients ages ≥18 with a BC-related pathogenic variant, without a concurrent or prior BC diagnosis, were identified from a single academic center's database. Patients were stratified by BRCA mutations, high penetrance mutations (HPM), and moderate penetrance mutations (MPM). Race and ethnicity were classified as non-Hispanic White (NHW), non-Hispanic Black (NHB), non-Hispanic other (NHO), and Hispanic.
RESULTS
Our study included 528 patients, which included 79.2 % (n = 418) NHW, 7.0 % (n = 37) NHB, 3.6 % (n = 19) NHO, and 3.4 % (n = 18) Hispanic patients. Overall, 16.5 % of patients underwent RRM: 18.4 % of NHW, 10.8 % of NHB, 5.6 % of Hispanic (p = 0.45). For NHB and Hispanic patients, no individuals with HPMs (NHB 0/6, Hispanic 0/5) or MPMs (NHB 0/11, Hispanic 0/4) underwent RRM.
CONCLUSIONS
Our findings suggest that race and ethnicity may be associated with the decision to undergo RRM.
引言
我们比较了患有乳腺癌（BC）相关致病变异患者的降低风险乳房切除术（RRM）发生率。
方法
从一个学术中心的数据库中识别出年龄≥18岁、患有BC相关致病变异且无同时期或既往BC诊断的女性患者。患者按BRCA突变、高 penetrance 突变（HPM）和中等 penetrance 突变（MPM）进行分层。种族和族裔分为非西班牙裔白人（NHW）、非西班牙裔黑人（NHB）、非西班牙裔其他（NHO）和西班牙裔。
结果
我们的研究纳入了528名患者，其中包括79.2%（n = 418）的NHW、7.0%（n = 37）的NHB、3.6%（n = 19）的NHO和3.4%（n = 18）的西班牙裔患者。总体而言，16.5%的患者接受了RRM：NHW为18.4%，NHB为10.8%，西班牙裔为5.6%（p = 0.45）。对于NHB和西班牙裔患者，没有携带HPMs（NHB为0/6，西班牙裔为0/5）或MPMs（NHB为0/11，西班牙裔为0/4）的个体接受RRM。
结论
我们的研究结果表明，种族和族裔可能与接受RRM的决定有关。
Zotero 插件