Aghaee A, Bakhshi Z, Roshanravan V, Norouzbeigi N, Dadgar H, Askari E, Aryana K, Shafiei S, Soltani S, Sadeghpour S
Nuclear Medicine Research Center, Mashhad University of Medical Sciences, Mashhad, Khorasan Razavi, Iran.
Razavi Cancer Research Center, Razavi Hospital, Imam Reza International University, Mashhad, Iran.
Rev Esp Med Nucl Imagen Mol (Engl Ed). 2025 Jun 20:500184. doi: 10.1016/j.remnie.2025.500184.
This study aims to evaluate the diagnostic value of early static and delayed imaging in conjunction with standard 68Ga-PSMA-11 PET/CT scans to detect prostate malignant lesions in prostate cancer patients.
One hundred and thirty-eight prostate cancer patients underwent routine [68 Ga]Ga-PSMA-11 PET/CT imaging, 4-minute static acquisition post-injection, and delayed imaging 3 h post-injection. The imaging results were analysed for lesion count, type, localisation, and maximum standardised uptake values.
57.97% exhibited positive findings for pathologic prostatic lesions in the standard PET scans (SUV: 10.24). In contrast, early PET imaging detected lesions in 58.01% of patients (SUV of 5.86), while delayed scans revealed lesions suggestive of malignancy in 55.45% of patients (SUV of 12.79). The analysis demonstrated a statistically significant difference in SUV values across the time points (P < .001). Pathologic lymph nodes on images 60 min p.i. were revealed by an SUV max 60 min p.i.: 15.78; this number for the first 4 min and after 3 h were 7.36, 19.19, respectively. Metastatic bone lesions on WB were found in 38 patients, more than the ESI (n = 37) and DI (n = 24). In comparison, urinary bladder activity assessment was detectable with the WB imaging SUV 60 min 11.07. Even though the SUV max for ESI and DI were 6.95 and 31.97, respectively. In the statistical analysis, pathologic radiotracer uptake in tumour lesions was statistically higher in ESI and WB than in urinary bladder activity.
The findings indicate that neither early [68 Ga]Ga-PSMA-11 PET/CT nor delayed imaging significantly enhanced the overall detection rate of malignant lesions in prostate cancer patients. However, the early 4-minute post-injection acquisition of PET images proved beneficial for distinguishing local bladder invasion more effectively.
本研究旨在评估早期静态成像和延迟成像结合标准68Ga-PSMA-11 PET/CT扫描对前列腺癌患者前列腺恶性病变的诊断价值。
138例前列腺癌患者接受了常规的[68Ga]Ga-PSMA-11 PET/CT成像、注射后4分钟的静态采集以及注射后3小时的延迟成像。对成像结果进行病变数量、类型、定位和最大标准化摄取值分析。
57.97%的患者在标准PET扫描中显示前列腺病变病理结果为阳性（SUV：10.24）。相比之下，早期PET成像在58.01%的患者中检测到病变（SUV为5.86），而延迟扫描在55.45%的患者中发现提示恶性的病变（SUV为12.79）。分析表明，各时间点的SUV值存在统计学显著差异（P<0.001）。注射后60分钟图像上的病理性淋巴结，注射后60分钟SUV最大值为15.78；注射后前4分钟和3小时后的该数值分别为7.36、19.19。全身骨显像发现38例患者有骨转移病变，多于早期静态成像（n=37）和延迟成像（n=24）。相比之下，全身骨显像注射后60分钟SUV为11.07时可检测到膀胱活动。尽管早期静态成像和延迟成像的SUV最大值分别为6.95和31.97。在统计分析中，肿瘤病变中的病理性放射性示踪剂摄取在早期静态成像和全身骨显像中在统计学上高于膀胱活动。
研究结果表明，早期[68Ga]Ga-PSMA-11 PET/CT和延迟成像均未显著提高前列腺癌患者恶性病变的总体检出率。然而，注射后早期4分钟的PET图像采集被证明更有利于更有效地鉴别局部膀胱侵犯。
