Zhang Y, Liu G, Zhong L, Li B, Zhang Y
Department of Nuclear Medicine, Zhongshan Hospital (Xiamen), Fudan University, Xiamen, Fujian, China; Clinical Research Center for Precision medicine of abdominal tumor of Fujian Province, Xiamen, Fujian, China.
Department of Nuclear Medicine, Zhongshan Hospital, Fudan University, Shanghai, China; Nuclear Medicine Institute of Fudan University, Shanghai, China; Shanghai Institute of Medical Imaging, Shanghai, China.
Rev Esp Med Nucl Imagen Mol (Engl Ed). 2025 Jun 20:500198. doi: 10.1016/j.remnie.2025.500198.
To investigate the prognostic value of pretreatment 2-[F]-fluoro-2-deoxy-d-glucose (F-FDG) positron emission tomography/computed tomography (PET/CT) in patients with hepatic neuroendocrine tumors (HNET).
In total, 41 patients were included in this study. PET-derived metabolic parameters, including maximum and mean standardized uptake values (SUV and SUV, respectively), metabolic tumor volume (MTV), and total lesion glycolysis (TLG), of the tumors were measured. Meanwhile, clinical data, including tumor pathological findings such as the Ki-67 index were also assessed. Progression-free survival (PFS) and overall survival (OS) were evaluated. Univariate and multivariate analyses were performed to predict the prognostic value of clinical variables and PET-derived metabolic parameters in HNET patients. Correlation between PET-derived metabolic parameters and Ki-67 was estimated.
Univariate analyses revealed that among PET-derived metabolic parameters, SUV, SUV, and TLG were significant prognostic factors for OS (P < .05). Among clinical variables, the Ki-67 index and radical surgical resection were significant factors for both PFS and OS (P < .05). In multivariate analyses, only Ki-67 index was an independent prognostic factor for both PFS and OS (P < .05). Ki-67 index presented correlates with SUV and SUV (R = 0.566, P < .001, R = 0.493, P = .001, respectively).
In patients with HNET, the Ki-67 index was an independent prognostic factor for both PFS and OS, while SUV, SUV, and TLG measured on pretreatment F-FDG PET/CT scans were prognostic factors for predicting OS. Ki-67 index also presented correlates with SUV and SUV. F-FDG-PET may be useful as quantitative predicting prognostic imaging biomarkers, especially in poorly differentiated HNET.
探讨预处理2-[F]-氟-2-脱氧-D-葡萄糖（F-FDG）正电子发射断层扫描/计算机断层扫描（PET/CT）对肝神经内分泌肿瘤（HNET）患者的预后价值。
本研究共纳入41例患者。测量肿瘤的PET衍生代谢参数，包括最大和平均标准化摄取值（分别为SUVmax和SUVmean）、代谢肿瘤体积（MTV）和总病变糖酵解（TLG）。同时，评估临床数据，包括肿瘤病理结果如Ki-67指数。评估无进展生存期（PFS）和总生存期（OS）。进行单因素和多因素分析以预测临床变量和PET衍生代谢参数对HNET患者的预后价值。估计PET衍生代谢参数与Ki-67之间的相关性。
单因素分析显示，在PET衍生代谢参数中，SUVmax、SUVmean和TLG是OS的显著预后因素（P<0.05）。在临床变量中，Ki-67指数和根治性手术切除是PFS和OS的显著因素（P<0.05）。多因素分析中，只有Ki-67指数是PFS和OS的独立预后因素（P<0.05）。Ki-67指数与SUVmax和SUVmean呈相关性（R分别为0.566，P<0.001；R为0.493，P=0.001）。
在HNET患者中，Ki-67指数是PFS和OS的独立预后因素，而预处理F-FDG PET/CT扫描测量的SUVmax、SUVmean和TLG是预测OS的预后因素。Ki-67指数也与SUVmax和SUVmean呈相关性。F-FDG-PET可能作为定量预测预后的影像生物标志物有用，尤其是在低分化HNET中。
