Coyle Patricia K
Stony Brook University Renaissance School of Medicine, Stony Brook, New York, United States.
Neurotherapeutics. 2025 Jul;22(4):e00620. doi: 10.1016/j.neurot.2025.e00620. Epub 2025 Jun 21.
Multiple sclerosis (MS) is a female predominant disease. The prototypic affected individual is a young woman of childbearing age. This article emphasizes the current thinking about this disease, using a sex-based approach. It begins with a review of male vs. female differences in the nervous system and immune system, as well as a general discussion of sex hormones. The demographic and clinical impact of sex on MS prognosis and symptoms is covered. Pregnancy, the best studied sex-based condition, is reviewed and includes updated counseling information on fertility and assisted reproductive technology. MS issues in less well studied areas involving puberty, the menstrual cycle and menopause are also presented. The impact of sex on the MS therapeutic response is considered. The final section covers MS considerations in males. This up to date review provides a comprehensive and succinct approach to sex considerations in MS.
多发性硬化症（MS）是一种女性为主的疾病。典型的患病个体是育龄期年轻女性。本文采用基于性别的方法，强调对这种疾病的当前认识。文章首先回顾了男性与女性在神经系统和免疫系统方面的差异，以及对性激素的总体讨论。涵盖了性别对MS预后和症状的人口统计学及临床影响。对研究最多的基于性别的情况——妊娠进行了综述，包括有关生育和辅助生殖技术的最新咨询信息。还介绍了在研究较少的领域，如青春期、月经周期和更年期中与MS相关的问题。探讨了性别对MS治疗反应的影响。最后一部分涵盖了男性MS的相关考量。这篇最新综述提供了一种全面而简洁的方法来考虑MS中的性别因素。
