Shen Zheng, Song Qingyu, Zhang Guangheng, Xin Chenglong, Wei Jiale, Wang Jian
College of Acupuncture and Massage, Shandong University of Traditional Chinese Medicine, Jinan, China.
Shanghai Seventh People's Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai, China.
J Med Virol. 2025 Jun;97(6):e70458. doi: 10.1002/jmv.70458.
Varicella-zoster virus infection (VZVI) has been demonstrated to result in the onset of varicella and zoster, which has a significant impact on global public health. The objective of this study was to comprehensively analyze the disease burden of VZVI, to predict future trends, and to propose prevention and control strategies. A variety of statistical methods were employed to assess the burden of disease using data from the Global Burden of Disease (GBD) 2021 database. The methods employed encompassed the analysis of its correlation with the socio-demographic index (SDI), the quantification of health inequalities, and the prediction of future trends. The findings indicate a global increase in the number of VZVI incident cases, accompanied by a decline in disability-adjusted life years (DALYs) and death rates from 1990 to 2021. The burden of disease exhibits significant variation across regions and countries, driven by factors such as population growth and epidemiological change. The findings of this study demonstrate the persistence of regional and age disparities and inequalities in the global burden of disease from VZVI, underscoring the necessity for enhanced management of low SDI regions. The study emphasizes the imperative for universal varicella vaccination, targeting children, as well as middle-aged and older adults. Furthermore, it emphasizes the necessity of enhancing preventive and control measures in high-risk areas and optimizing the allocation of healthcare resources to address health inequalities.
水痘带状疱疹病毒感染（VZVI）已被证明会导致水痘和带状疱疹的发病，这对全球公共卫生有重大影响。本研究的目的是全面分析VZVI的疾病负担，预测未来趋势，并提出预防和控制策略。采用了多种统计方法，利用全球疾病负担（GBD）2021数据库的数据评估疾病负担。所采用的方法包括分析其与社会人口指数（SDI）的相关性、量化健康不平等以及预测未来趋势。研究结果表明，1990年至2021年期间，VZVI发病病例数在全球范围内有所增加，同时伤残调整生命年（DALYs）和死亡率有所下降。疾病负担在不同地区和国家存在显著差异，受人口增长和流行病学变化等因素驱动。本研究结果表明，VZVI全球疾病负担中区域和年龄差异及不平等现象持续存在，强调了加强对低SDI地区管理的必要性。该研究强调了针对儿童以及中年和老年人进行普遍水痘疫苗接种的必要性。此外，它强调了加强高风险地区预防和控制措施以及优化医疗资源分配以解决健康不平等问题的必要性。
